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Dehydroemetine
🥰Excellent
Catalog No. T15095Cas No. 4914-30-1
Dehydroemetine is an effective antigenic insecticide, which is a synthetic analogue of Emetine dihydrochloride. It can be used to prevent and treat amoeba infections and diseases. It has the effect of treating leishmania infection with skin damage and resistance to metronidazole amoebiosis.
Dehydroemetine
🥰Excellent
Purity: 99.58%
Catalog No. T15095Cas No. 4914-30-1
Dehydroemetine is an effective antigenic insecticide, which is a synthetic analogue of Emetine dihydrochloride. It can be used to prevent and treat amoeba infections and diseases. It has the effect of treating leishmania infection with skin damage and resistance to metronidazole amoebiosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $129 | In Stock | |
| 5 mg | $322 | In Stock | |
| 10 mg | $487 | In Stock | |
| 25 mg | $750 | In Stock | |
| 50 mg | $987 | In Stock | |
| 100 mg | $1,350 | In Stock | |
| 500 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $355 | In Stock |
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Purity:99.58%
ee:99.28%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dehydroemetine is an effective antigenic insecticide, which is a synthetic analogue of Emetine dihydrochloride. It can be used to prevent and treat amoeba infections and diseases. It has the effect of treating leishmania infection with skin damage and resistance to metronidazole amoebiosis. |
| In vivo | The mechanism of the inhibitory effect of Dehydroemetine on the heart was investigated using (a) the spontaneously contracting isolated guinea-pig atrial preparation and (b), the electrically driven left atrial preparation. Dehydroemetine decreased the rate and amplitude of contraction of spontaneously contracting atria. Increasing the calcium concentration of the bath fluid to 28.2 mM abolished the effect of Dehydroemetine on the amplitude of contraction while the effect on the rate persisted. Pretreatment with Dehydroemetine increased the capacity of ouabain to induce arrhythmias in spontaneously contracting atria. Similarly, pretreatment with ouabain augmented the inhibitory effect of Dehydroemetine on spontaneous atrial activity. In the electrically driven left atrial preparation, Dehydroemetine caused a decrease in contractile strength which was opposed by ouabain and by increased calcium concentration of the bath fluid. The effect of Dehydroemetine on spontaneously contracting and on electrically driven atria was mimicked by adding excess potassium to the bath fluid. It was concluded that the effects of Dehydroemetine on rate and contractility are, to a large extent, independent of one another. The effect on spontaneous rate is consistent with alteration of the potassium permeability of the myocardial cell membrane while the effect on contractility appears to be due to a decrease in the uptake of calcium from the medium by the myocardial cell.[1] |
| Molecular Weight | 478.62 |
| Formula | C29H38N2O4 |
| Cas No. | 4914-30-1 |
| Smiles | [H][C@@]12CC(C[C@H]3NCCc4cc(OC)c(OC)cc34)=C(CC)CN1CCc1cc(OC)c(OC)cc21 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (52.23 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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