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Dehydroevodiamine hydrochloride

Catalog No. T5721Cas No. 111664-82-5

Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.

Dehydroevodiamine hydrochloride

Dehydroevodiamine hydrochloride

Catalog No. T5721Cas No. 111664-82-5
Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.
Pack SizePriceAvailabilityQuantity
5 mg$35In Stock
10 mg$48In Stock
25 mg$90In Stock
50 mg$132In Stock
100 mg$195In Stock
1 mL x 10 mM (in DMSO)$40In Stock
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Purity:≥95%
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Product Introduction

Bioactivity
Description
Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitric oxide production.
In vivo
Dehydroevodiaminehydrochloride has strong protective effects against cognitive impairments through its antioxidant activity and inhibition of neurotoxicity and intracellular calcium. Thus, DHED may be an important therapeutic agent for memory-impaired symptoms.
Animal Research
The effects of dehydroevodiamine·HCl (DHED) on cognitive improvement and the related mechanism in memory-impaired rat models, namely, a scopolamine-induced amnesia model and a Aβ1-42-infused model. The cognitive effects of DHED were measured using a water maze test and a passive avoidance test in the memory-impaired rat models. The results demonstrate that DHED (10 mg/kg, p.o.) and Donepezil (1 mg/kg, p.o.) ameliorated the spatial memory impairment in the scopolamine-induced amnestic rats.
Chemical Properties
Molecular Weight337.8
FormulaC19H16ClN3O
Cas No.111664-82-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 37 mg/mL (109.53 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9603 mL14.8017 mL29.6033 mL148.0166 mL
5 mM0.5921 mL2.9603 mL5.9207 mL29.6033 mL
10 mM0.2960 mL1.4802 mL2.9603 mL14.8017 mL
20 mM0.1480 mL0.7401 mL1.4802 mL7.4008 mL
50 mM0.0592 mL0.2960 mL0.5921 mL2.9603 mL
100 mM0.0296 mL0.1480 mL0.2960 mL1.4802 mL

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