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DHODH-IN-14

DHODH-IN-14
DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.
Catalog No. T11023Cas No. 1364791-93-4
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Purity:99.87%
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DHODH-IN-14

Purity: 99.87%
Catalog No. T11023Cas No. 1364791-93-4

DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.
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Pack SizePriceAvailabilityQuantity
1 mg$117In Stock
2 mg$175In Stock
5 mg$269In Stock
10 mg$395In Stock
25 mg$592In Stock
50 mg$834In Stock
100 mg$1,120In Stock
500 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$277In Stock
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Product Introduction

Bioactivity
Description
DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.
Targets&IC50
DHODH (rat liver):0.49 μM
In vitro
DHODH-IN-14 is a hydroxyfuran analog of A771726, which contains a biphenyl scaffold with a fluorine substituent. Turning to the derivative DHODH-IN-14, no major differences were observed between the poses obtained on 1UUO and 1D3G. In both cases, it was found that DHODH-IN-14 was bound in a BQN-like manner, that is, the deprotonated hydroxyfuran part faced Arg136, thus effectively mimicking the carboxyl groups of BQN and related compounds. Although it was not found on 1D3G and 1UUO that hydroxyfuran interacted with Tyr356 in a similar way to leflunomide, when 2BXV was used as a docking target, a large portion of such postures were found[1].
Chemical Properties
Molecular Weight353.23
FormulaC15H7F4N3O3
Cas No.1364791-93-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (141.55 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8310 mL14.1551 mL28.3102 mL141.5508 mL
5 mM0.5662 mL2.8310 mL5.6620 mL28.3102 mL
10 mM0.2831 mL1.4155 mL2.8310 mL14.1551 mL
20 mM0.1416 mL0.7078 mL1.4155 mL7.0775 mL
50 mM0.0566 mL0.2831 mL0.5662 mL2.8310 mL
100 mM0.0283 mL0.1416 mL0.2831 mL1.4155 mL

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