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Isoquinoline, 5-iodo- is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $45 | In Stock | |
100 mg | $72 | In Stock | |
200 mg | $97 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Isoquinoline, 5-iodo- is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons. |
Targets&IC50 | SARM1:75 nM, CADPR increase:2.8 μM |
In vitro | Treatment with the isoquinoline DSRM-3716produced dose-dependent inhibition of cADPR increase (IC50 = 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells. DSRM-3716prevented NfL release from severed axons in a dose-dependent manner[1]. |
Molecular Weight | 255.06 |
Formula | C9H6IN |
Cas No. | 58142-99-7 |
Smiles | IC1=CC=CC2=CN=CC=C12 |
Relative Density. | 1.837 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (196.03 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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