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DSRM-3716

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COA HPLC

DSRM-3716

Catalog No. T8860Cas No. 58142-99-7

Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.

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Pack Size	Price	Availability
50 mg	$45	In Stock
100 mg	$72	In Stock
200 mg	$97	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.
In vitro	Treatment with the isoquinoline Isoquinoline, 5-iodo- (9CI) produced dose-dependent inhibition of cADPR increase (IC50 = 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells. Isoquinoline, 5-iodo- (9CI) prevented NfL release from severed axons in a dose-dependent manner[1].

Chemical Properties

Molecular Weight	255.06
Formula	C9H6IN
Cas No.	58142-99-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (196.03 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9206 mL	19.6032 mL	39.2065 mL	196.0323 mL
5 mM	0.7841 mL	3.9206 mL	7.8413 mL	39.2065 mL
10 mM	0.3921 mL	1.9603 mL	3.9206 mL	19.6032 mL
20 mM	0.1960 mL	0.9802 mL	1.9603 mL	9.8016 mL
50 mM	0.0784 mL	0.3921 mL	0.7841 mL	3.9206 mL
100 mM	0.0392 mL	0.1960 mL	0.3921 mL	1.9603 mL

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