Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

DSRM-3716

🥰Excellent
Catalog No. T8860Cas No. 58142-99-7

Isoquinoline, 5-iodo- is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.

DSRM-3716

DSRM-3716

🥰Excellent
Purity: 99.74%
Catalog No. T8860Cas No. 58142-99-7
Isoquinoline, 5-iodo- is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.
Pack SizePriceAvailabilityQuantity
50 mg$45In Stock
100 mg$72In Stock
200 mg$97In Stock
1 mL x 10 mM (in DMSO)$50In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "DSRM-3716"

Select Batch
Purity:99.74%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Isoquinoline, 5-iodo- is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.
Targets&IC50
SARM1:75 nM, CADPR increase:2.8 μM
In vitro
Treatment with the isoquinoline DSRM-3716produced dose-dependent inhibition of cADPR increase (IC50 = 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells. DSRM-3716prevented NfL release from severed axons in a dose-dependent manner[1].
Chemical Properties
Molecular Weight255.06
FormulaC9H6IN
Cas No.58142-99-7
SmilesIC1=CC=CC2=CN=CC=C12
Relative Density.1.837 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (196.03 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.9206 mL19.6032 mL39.2065 mL196.0323 mL
5 mM0.7841 mL3.9206 mL7.8413 mL39.2065 mL
10 mM0.3921 mL1.9603 mL3.9206 mL19.6032 mL
20 mM0.1960 mL0.9802 mL1.9603 mL9.8016 mL
50 mM0.0784 mL0.3921 mL0.7841 mL3.9206 mL
100 mM0.0392 mL0.1960 mL0.3921 mL1.9603 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy DSRM-3716 | purchase DSRM-3716 | DSRM-3716 cost | order DSRM-3716 | DSRM-3716 chemical structure | DSRM-3716 in vitro | DSRM-3716 formula | DSRM-3716 molecular weight