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DTP3
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Catalog No. T22319Cas No. 1809784-29-9
DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.
DTP3
😃Good
Catalog No. T22319Cas No. 1809784-29-9
DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | 72 € | 5 days | |
| 5 mg | 121 € | 5 days | |
| 10 mg | 216 € | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway. |
| In vitro | DTP3 physically interacts with MKK7 in isolation and within the complex with GADD45β, and dissociates the GADD45β/MKK7 complex via an allosteric mechanism. DTP3 selectively kills cells and induces apoptosis in MM cells with functional MKK7 and elevated GADD45β expression without toxicity to normal cells. In addition, DTP3 displays synergistic activity with bortezomib in two different MM cell lines, exhibiting a combination index of 0.56 in KMS-12 cells and of 0.21 in U266 cells. [1] |
| In vivo | DTP3 treatment with 14.5 mg/kg/day exhibits potent antitumor activity against MM in mouse plasmacytoma model. [1] |
| Molecular Weight | 525.6 |
| Formula | C26H35N7O5 |
| Cas No. | 1809784-29-9 |
| Relative Density. | 1.35 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 100 mg/ml (190.26 mM) H2O: 100 mg/ml (190.26 mM) DMSO: 100 mg/ml (190.26 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/H2O/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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