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Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 37 € | In Stock | |
5 mg | 64 € | In Stock | |
10 mg | 92 € | In Stock | |
25 mg | 151 € | In Stock | |
50 mg | 221 € | In Stock | |
1 mL x 10 mM (in DMSO) | 70 € | In Stock |
Description | Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC. |
Targets&IC50 | Topo I:0.31 μM |
In vitro | Dxd shows obviously suppression on the HER2-positive KPL-4, NCI-N87, and SK-BR-3 cell lines with IC50s of 26.8, 25.4, and 6.7 ng/mL respectively, but with no such inhibition on MDA-MB-468 (IC50, >10,000 ng/mL)[1]. |
In vivo | Dxd is cytotoxic to human cancer cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC50s of 1.43 nM-4.07 nM. In HER2 low-expressing ST565 and ST313 models has HER2 IHC 1+/FISH-negative expression[1]. |
Alias | UNII-OQM5SD32BQ, OQM5SD32BQ, Exatecan derivative for ADC |
Molecular Weight | 493.48 |
Formula | C26H24FN3O6 |
Cas No. | 1599440-33-1 |
Smiles | CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](NC(=O)CO)c(c3Cn1c2=O)c45 |
Relative Density. | 1.57 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: insoluble DMSO: 50 mg/mL (101.32 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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