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Dxd

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Purity:100%

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COA HPLC HNMR

Dxd

Catalog No. T11249LCas No. 1599440-33-1

Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC.

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Pack Size	Price	Availability
1 mg	$39	In Stock
5 mg	$68	In Stock
10 mg	$97	In Stock
25 mg	$159	In Stock
50 mg	$233	In Stock
1 mL x 10 mM (in DMSO)	$74	In Stock

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Product Introduction

Bioactivity

Description	Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC.
In vitro	Dxd shows obviously suppression on the HER2-positive KPL-4, NCI-N87, and SK-BR-3 cell lines with IC50s of 26.8, 25.4, and 6.7 ng/mL respectively, but with no such inhibition on MDA-MB-468 (IC50, >10,000 ng/mL)[1].
In vivo	Dxd is cytotoxic to human cancer cell lines of KPL-4, NCI-N87, SK-BR-3, and MDA-MB-468 with IC50s of 1.43 nM-4.07 nM. In HER2 low-expressing ST565 and ST313 models has HER2 IHC 1+/FISH-negative expression[1].
Alias	Exatecan derivative for ADC, OQM5SD32BQ, UNII-OQM5SD32BQ

Chemical Properties

Molecular Weight	493.48
Formula	C26H24FN3O6
Cas No.	1599440-33-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: insoluble

DMSO: 50 mg/mL (101.32 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0264 mL	10.1321 mL	20.2642 mL	101.3212 mL
5 mM	0.4053 mL	2.0264 mL	4.0528 mL	20.2642 mL
10 mM	0.2026 mL	1.0132 mL	2.0264 mL	10.1321 mL
20 mM	0.1013 mL	0.5066 mL	1.0132 mL	5.0661 mL
50 mM	0.0405 mL	0.2026 mL	0.4053 mL	2.0264 mL
100 mM	0.0203 mL	0.1013 mL	0.2026 mL	1.0132 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc