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Eact
🥰Excellent
Catalog No. T15192Cas No. 461000-66-8
Eact is a selective and potent TMEM16A activator that directly activates the TRPV1 channels in sensory nociceptors, thereby producing itch, acute nociception, and thermal hypersensitivity (brackets).
Eact
🥰Excellent
Purity: 98.62%
Catalog No. T15192Cas No. 461000-66-8
Eact is a selective and potent TMEM16A activator that directly activates the TRPV1 channels in sensory nociceptors, thereby producing itch, acute nociception, and thermal hypersensitivity (brackets).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $31 | In Stock | |
| 2 mg | $44 | In Stock | |
| 5 mg | $72 | In Stock | |
| 10 mg | $128 | In Stock | |
| 25 mg | $267 | In Stock | |
| 50 mg | $452 | In Stock | |
| 100 mg | $665 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $79 | In Stock |
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Purity:98.62%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Eact is a selective and potent TMEM16A activator that directly activates the TRPV1 channels in sensory nociceptors, thereby producing itch, acute nociception, and thermal hypersensitivity (brackets). |
| In vitro | Eact activates membrane currents in mTRPV1-expressing HEK293T cells in a concentration-dependent manner (EC50: 11.6 ± 2.5 μM). Eact induces both itch-and pain- related behaviours in a TRPV1-dependent manner. TMEM16A activator Eact activates both native and recombinant TRPV1 channels[1]. |
| Molecular Weight | 428.5 |
| Formula | C22H24N2O5S |
| Cas No. | 461000-66-8 |
| Smiles | COCCN(C(=O)c1cc(OC)c(OC)c(OC)c1)c1nc(cs1)-c1ccccc1 |
| Relative Density. | 1.237 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (116.69 mM), Sonication is recommended. H2O: Insoluble  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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