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Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $36 | In Stock | |
10 mg | $61 | In Stock | |
25 mg | $117 | In Stock | |
50 mg | $191 | In Stock | |
100 mg | $298 | In Stock | |
1 mL x 10 mM (in DMSO) | $51 | In Stock |
Description | Afoxolaner is an isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect GABA and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod. |
In vivo | A single oral administration of afoxolaner at a dose near the minimum effective (2.5mg/kg) eradicated existing I. scapularis tick infestations and managed weekly re-infestations effectively. Efficiencies ranged from 98% to 100% up to Day 23 and remained at 94% on Day 30 [1]. |
Molecular Weight | 625.87 |
Formula | C26H17ClF9N3O3 |
Cas No. | 1093861-60-9 |
Smiles | FC(F)(F)CNC(=O)CNC(=O)c1ccc(C2=NOC(C2)(c2cc(Cl)cc(c2)C(F)(F)F)C(F)(F)F)c2ccccc12 |
Relative Density. | 1.53 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: ≥ 250 mg/mL (399.44 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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