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Ecdysone

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Catalog No. TN3910Cas No. 3604-87-3

Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.

Ecdysone

Ecdysone

😃Good
Catalog No. TN3910Cas No. 3604-87-3
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.
Pack SizePriceAvailabilityQuantity
1 mg$13335 days
5 mg$44335 days
10 mg$75035 days
25 mg$1,56035 days
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Product Introduction

Bioactivity
Description
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.
In vitro
Ecdysone (10, 100 nM) induced the expression of a-smooth muscle actin (SMA). Ecdysone elevated the expression of cleaved caspase 3 in a dose dependent manner. Ecdysone (10, 100 nM) suppressed cell motility and scratch wound closure to a comparable extent[4]. Ecdysone (100 nM) induced a branched spindle mesenchymal-like cell shape. Ecdysone (100 nM) caused renal tubular inner medullary collecting duct cells apoptosis[4].
In vivo
In male C57BL/6 mice, Ecdysone (6 μg/g/day; s.c.) significantly impaired renal function, and BUN levels were statistically significantly increased, amplifying the renal expression of α-SMA. Ecdysone also displayed MR-dependent nephrotic effects[4].
Chemical Properties
Molecular Weight464.63
FormulaC27H44O6
Cas No.3604-87-3
Relative Density.1.22g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/ml (129.14 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1523 mL10.7613 mL21.5225 mL107.6125 mL
5 mM0.4305 mL2.1523 mL4.3045 mL21.5225 mL
10 mM0.2152 mL1.0761 mL2.1523 mL10.7613 mL
20 mM0.1076 mL0.5381 mL1.0761 mL5.3806 mL
50 mM0.0430 mL0.2152 mL0.4305 mL2.1523 mL
100 mM0.0215 mL0.1076 mL0.2152 mL1.0761 mL

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