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Ecdysone

Catalog No. TN3910Cas No. 3604-87-3

Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.

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Pack Size	Price	Availability
1 mg	$133	35 days
5 mg	$443	35 days
10 mg	$750	35 days
25 mg	$1,560	35 days

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Product Introduction

Bioactivity

Description	Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death.
In vitro	Ecdysone (10, 100 nM) induced the expression of a-smooth muscle actin (SMA). Ecdysone elevated the expression of cleaved caspase 3 in a dose dependent manner. Ecdysone (10, 100 nM) suppressed cell motility and scratch wound closure to a comparable extent[4]. Ecdysone (100 nM) induced a branched spindle mesenchymal-like cell shape. Ecdysone (100 nM) caused renal tubular inner medullary collecting duct cells apoptosis[4].
In vivo	In male C57BL/6 mice, Ecdysone (6 μg/g/day; s.c.) significantly impaired renal function, and BUN levels were statistically significantly increased, amplifying the renal expression of α-SMA. Ecdysone also displayed MR-dependent nephrotic effects[4].

Chemical Properties

Molecular Weight	464.63
Formula	C27H44O6
Cas No.	3604-87-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (129.14 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1523 mL	10.7613 mL	21.5225 mL	107.6125 mL
5 mM	0.4305 mL	2.1523 mL	4.3045 mL	21.5225 mL
10 mM	0.2152 mL	1.0761 mL	2.1523 mL	10.7613 mL
20 mM	0.1076 mL	0.5381 mL	1.0761 mL	5.3806 mL
50 mM	0.0430 mL	0.2152 mL	0.4305 mL	2.1523 mL
100 mM	0.0215 mL	0.1076 mL	0.2152 mL	1.0761 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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Ecdysone