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Efaproxiral
🥰Excellent
Catalog No. T21318Cas No. 131179-95-8
Alias RSR-13, RSR13, GSJ61, GSJ 61, Efaproxyn
Efaproxiral (RSR13) is a hemoglobin allosteric modifier, a potential radiosensitizer and chemotherapy enhancer in cancer treatment, improving tumor oxygenation.
Efaproxiral
🥰Excellent
Catalog No. T21318Alias RSR-13, RSR13, GSJ61, GSJ 61, EfaproxynCas No. 131179-95-8
Efaproxiral (RSR13) is a hemoglobin allosteric modifier, a potential radiosensitizer and chemotherapy enhancer in cancer treatment, improving tumor oxygenation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $30 | In Stock | |
| 25 mg | $46 | In Stock | |
| 50 mg | $71 | In Stock | |
| 100 mg | $98 | In Stock | |
| 200 mg | $152 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $74 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Efaproxiral (RSR13) is a hemoglobin allosteric modifier, a potential radiosensitizer and chemotherapy enhancer in cancer treatment, improving tumor oxygenation. |
| Targets&IC50 | INS1 (832/13) cells:6 nM (EC50) |
| In vivo | Treatment with Efaproxiral(150 mg/kg, ip) significantly increased oxygenation in RIF-1 tumors implanted in C3H mice and increased the ability of radiotherapy to inhibit tumor growth within 5 days. [1] Efaproxiral may increase the oxygenation capacity of intracranial tumors. [2] |
| Alias | RSR-13, RSR13, GSJ61, GSJ 61, Efaproxyn |
| Molecular Weight | 341.4 |
| Formula | C20H23NO4 |
| Cas No. | 131179-95-8 |
| Smiles | O=C(O)C(OC1=CC=C(C=C1)CC(=O)NC=2C=C(C=C(C2)C)C)(C)C |
| Relative Density. | 1.202 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble) DMSO: 120 mg/mL (351.49 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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