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Elimusertib hydrochloride(1876467-74-1 free base)

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Purity:99.86%

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COA HNMR HPLC

Elimusertib hydrochloride(1876467-74-1 free base)

Catalog No. T10468

Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activity.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$51	In Stock
2 mg	$71	In Stock
5 mg	$135	In Stock
10 mg	$205	In Stock
25 mg	$413	In Stock
50 mg	$613	In Stock
100 mg	$873	In Stock
500 mg	$1,780	In Stock
1 mL x 10 mM (in DMSO)	$146	In Stock

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Product Introduction

Bioactivity

Description	Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activity.
In vitro	Elimusertib hydrochloride potently inhibits the proliferation of a broad spectrum of human tumor cell lines (median IC50: 78 nM). BAY-1895344 potently suppresses NSC-32065-induced H2AX phosphorylation (IC50: 36 nM) [1].
In vivo	In a variety of xenograft models of ovarian and colorectal cancer, Elimusertib hydrochloride shows potent anti-tumor efficacy in monotherapy and causes complete tumor remission in mantle cell lymphoma models [2].
Alias	BAY-1895344 hydrochloride

Chemical Properties

Molecular Weight	411.89
Formula	C20H22ClN7O
Cas No.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (121.39 mM)

H2O: 48 mg/mL (116.53 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.4278 mL	12.1392 mL	24.2783 mL	121.3916 mL
5 mM	0.4856 mL	2.4278 mL	4.8557 mL	24.2783 mL
10 mM	0.2428 mL	1.2139 mL	2.4278 mL	12.1392 mL
20 mM	0.1214 mL	0.6070 mL	1.2139 mL	6.0696 mL
50 mM	0.0486 mL	0.2428 mL	0.4856 mL	2.4278 mL
100 mM	0.0243 mL	0.1214 mL	0.2428 mL	1.2139 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc