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Epostane
🥰Excellent
Catalog No. T68664Cas No. 80471-63-2
Alias Win-32729
Epostane acts as an antiprogestogen and terminates pregnancy by inhibiting 3β-hydroxysteroid dehydrogenase and preventing the biosynthesis of progesterone and pregnenolone. [4]
Epostane
🥰Excellent
Purity: 100%
Catalog No. T68664Alias Win-32729Cas No. 80471-63-2
Epostane acts as an antiprogestogen and terminates pregnancy by inhibiting 3β-hydroxysteroid dehydrogenase and preventing the biosynthesis of progesterone and pregnenolone. [4]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $623 | In Stock | |
| 5 mg | $1,290 | In Stock | |
| 10 mg | $1,770 | In Stock | |
| 25 mg | $2,630 | In Stock | |
| 50 mg | $3,550 | In Stock | |
| 100 mg | $4,790 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Epostane acts as an antiprogestogen and terminates pregnancy by inhibiting 3β-hydroxysteroid dehydrogenase and preventing the biosynthesis of progesterone and pregnenolone. [4] |
| In vitro | METHODS: Using one fish oocyte, the ovary was cut into small pieces and incubated with Epostane (1 μg/mL), and the incidence of germinal vesicle breakdown (GVBD) was examined microscopically RESULTS Epostane induced a significant decrease in the frequency of GVBD in oocytes, but Epostane failed to eliminate the maturation effect of 17α,20 β-diOHprog, the most potent maturation-inducing steroid in this species. |
| In vivo | METHODS: A single-dose, randomized, double-blind study was conducted in which each woman awaiting termination of pregnancy was administered either 50 mg Epostane or 100 mg Epostane orally, and the effects of in vivo serum luteinizing hormone (P), estradiol (E2), and cortisol were determined. RESULTS Both serum P concentrations decreased significantly, and a similar decrease in serum E2 was observed, with subsequent normalization of E2. [1] METHODS: Seventy-eight healthy women were recruited to the study who were less than 49 days from their last menstrual period and requested termination of pregnancy, 200 mg Epostane four times daily for a total of 7 days. RESULTS The complete abortion rate in the Epostane group was 73%. [2] |
| Alias | Win-32729 |
| Molecular Weight | 357.49 |
| Formula | C22H31NO3 |
| Cas No. | 80471-63-2 |
| Smiles | C[C@@]12[C@]3([C@](C)(O3)C(O)=C(C#N)C1)CC[C@@]4([C@@]2(CC[C@@]5(C)[C@]4(CC[C@]5(C)O)[H])[H])[H] |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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