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Etalocib sodium

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Catalog No. T201014Cas No. 152608-41-8
Alias LY293111 sodium

Etalocib (LY293111) sodium is an orally active leukotriene B4 (LTB4) receptor antagonist with a Ki value of 25 nM for inhibiting [3H]LTB4 binding. It exhibits an IC50 of 20 nM against LTB4-induced calcium mobilization. Additionally, Etalocib sodium can induce apoptosis.

Etalocib sodium

Etalocib sodium

😃Good
Catalog No. T201014Alias LY293111 sodiumCas No. 152608-41-8
Etalocib (LY293111) sodium is an orally active leukotriene B4 (LTB4) receptor antagonist with a Ki value of 25 nM for inhibiting [3H]LTB4 binding. It exhibits an IC50 of 20 nM against LTB4-induced calcium mobilization. Additionally, Etalocib sodium can induce apoptosis.
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10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
Etalocib (LY293111) sodium is an orally active leukotriene B4 (LTB4) receptor antagonist with a Ki value of 25 nM for inhibiting [3H]LTB4 binding. It exhibits an IC50 of 20 nM against LTB4-induced calcium mobilization. Additionally, Etalocib sodium can induce apoptosis.
In vitro
Etalocib sodium exhibits concentration-dependent inhibition of LTB4-induced upregulation of CD11b. It acts as an extremely potent and selective antagonist of human neutrophil functions in vitro. Additionally, at concentrations of 250 and 500 nM over 24-72 hours, Etalocib sodium induces apoptosis and inhibits proliferation in human pancreatic cancer cells.
In vivo
Etalocib demonstrates dose-dependent attenuation of acute leukotriene B4-induced airway obstruction, with an (ED 50 =14 μg/kg) when given intravenously and an (ED 50 =0.4 mg/kg) when administered orally. At a dosage of 10 mg/kg, it reduces lung inflammation induced by A23187 within one hour. Furthermore, daily oral administration of Etalocib at 250 mg/kg effectively suppresses the growth of human pancreatic cancer xenografts in athymic mice.
AliasLY293111 sodium
Chemical Properties
Molecular Weight567.6
FormulaC33H33FNaO6
Cas No.152608-41-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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