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EW-7195

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Purity:98.76%

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COA HPLC HNMR

EW-7195

Catalog No. T38752Cas No. 1352609-28-9

EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-induced Smad signaling, epithelial mesenchymal transition (EMT), and breast cancer metastasis to the lungs.

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Pack Size	Price	Availability
1 mg	$133	In Stock
2 mg	$196	In Stock
5 mg	$328	In Stock
10 mg	$563	In Stock
25 mg	$1,120	In Stock
50 mg	$1,830	In Stock
100 mg	$2,890	In Stock
1 mL x 10 mM (in DMSO)	$363	In Stock

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Product Introduction

Bioactivity

Description	EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-induced Smad signaling, epithelial mesenchymal transition (EMT), and breast cancer metastasis to the lungs.
In vitro	In vitro, EW-7195 efficiently inhibits the epithelial-to-mesenchymal transition (EMT), motility, and invasiveness of breast cancer cells. Following a 1.5-hour treatment at concentrations of 0.5-1 µM, EW-7195 effectively blocks TGF-β1-induced phosphorylation of Smad2, subsequently preventing the nuclear translocation of Smad2/3. Additionally, EW-7195 hinders TGF-β1-induced mesenchymal morphology and transcriptional activation[1].
In vivo	In both 4T1 orthotopic xenograft and MMTV/cNeu transgenic mice, EW7195 (40 mg/kg; intraperitoneal; three times a week for 3/2.5 weeks) inhibits the development of lung metastasis[1].

Chemical Properties

Molecular Weight	406.44
Formula	C23H18N8
Cas No.	1352609-28-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (98.42 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4604 mL	12.3019 mL	24.6039 mL	123.0194 mL
5 mM	0.4921 mL	2.4604 mL	4.9208 mL	24.6039 mL
10 mM	0.2460 mL	1.2302 mL	2.4604 mL	12.3019 mL
20 mM	0.1230 mL	0.6151 mL	1.2302 mL	6.1510 mL
50 mM	0.0492 mL	0.2460 mL	0.4921 mL	2.4604 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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