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Fanotaprim

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COA HNMR

Fanotaprim

Catalog No. T36692Cas No. 2120282-75-7

Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio of 196.

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Pack Size	Price	Availability
1 mg	$80	In Stock
5 mg	$197	In Stock
10 mg	$313	In Stock
25 mg	$588	In Stock
50 mg	$838	In Stock
100 mg	$1,160	In Stock
1 mL x 10 mM (in DMSO)	$217	In Stock

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Product Introduction

Bioactivity

Description	Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio of 196.
In vitro	Fanotaprim shows parasiticidal and antiproliferative effects with EC50s of 13 and 7300 nM against the type I RH strain of T. gondii and MCF-7 cells, respectively[1].Fanotaprim shows ability to inhibit the growth of T. gondii strains in vitro with EC50s ranging 7.6~ 29.8 nM (GT1, ME49, CTG, RUB and VAND)[1].
In vivo	Fanotaprim (1-10 mg/kg; p.o.; daily; beginning on day 1 through day 7) shows highly effective in control of acute infection by highly virulent strains of T. gondii in the murine model[1].Fanotaprim (1mg/kg; i.v; mouse) shows CL, Vd, and t1/2 values of 10.6 mL/min/kg, 1.14 L/kg, and 3.9 hours, respectively[1].Fanotaprim (0.83 mg/kg; p.o; mouse) shows F, Cmax, Tmax, and AUC0-last of 47.3%, 178 ng/mL, 0.05 hours and 750 ng h/mL, respectively[1].

Chemical Properties

Molecular Weight	378.43
Formula	C19H22N8O
Cas No.	2120282-75-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (66.06 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6425 mL	13.2125 mL	26.4250 mL	132.1248 mL
5 mM	0.5285 mL	2.6425 mL	5.2850 mL	26.4250 mL
10 mM	0.2642 mL	1.3212 mL	2.6425 mL	13.2125 mL
20 mM	0.1321 mL	0.6606 mL	1.3212 mL	6.6062 mL
50 mM	0.0528 mL	0.2642 mL	0.5285 mL	2.6425 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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