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FM04 is an orally active and highly potent inhibitor of P-glycoprotein (P-gp) with an EC50 value of 83 nM. FM04 can interact with Q1193 and I1115 in human P-gp nucleotide binding domain 2 (NBD2). Thereby disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling the ICL2-NBD2 interaction, thereby inhibiting P-gp. FM04 can be used in the treatment of cancer and tumors.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $483 | In Stock | |
10 mg | $692 | In Stock | |
25 mg | $1,080 | In Stock | |
50 mg | $1,490 | In Stock | |
100 mg | $1,970 | In Stock | |
500 mg | $3,930 | In Stock |
Description | FM04 is an orally active and highly potent inhibitor of P-glycoprotein (P-gp) with an EC50 value of 83 nM. FM04 can interact with Q1193 and I1115 in human P-gp nucleotide binding domain 2 (NBD2). Thereby disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling the ICL2-NBD2 interaction, thereby inhibiting P-gp. FM04 can be used in the treatment of cancer and tumors. |
Targets&IC50 | P-gp:83 nM(EC50) |
In vitro | FM04 (100 μM) exhibits competition with its photoaffinity derivative XC4 in LCC6MDR cells.[1] FM04 inhibits P-glycoprotein with an EC50=83 nM, where the EC50 value refers to the effective modulator concentration IC50 (=3.8 nM) that reduces paclitaxel (PTX) by half in the P-gp overexpressing cell line LCC6MDR.[1] |
Molecular Weight | 415.48 |
Formula | C26H25NO4 |
Cas No. | 1807320-40-6 |
Smiles | O=C1C=C(OC=2C1=CC=CC2)C3=CC=C(OCCOCCNCC4=CC=CC=C4)C=C3 |
Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (132.38 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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