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FR 122047

FR 122047
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Purity:99.63%
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FR 122047

Catalog No. T22790Cas No. 130717-51-0
FR 122047 (1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride) is a potent and selective inhibitor of COX-1 with IC50 of 28 nM and 65 µM for human recombinant COX-1 and COX-2, respectively.
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Pack SizePriceAvailabilityQuantity
1 mg$44In Stock
5 mg$105In Stock
10 mg$176In Stock
25 mg$359In Stock
50 mg$578In Stock
100 mg$828In Stock
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Product Introduction

Bioactivity
Description
FR 122047 (1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride) is a potent and selective inhibitor of COX-1 with IC50 of 28 nM and 65 µM for human recombinant COX-1 and COX-2, respectively.
Alias4,5-Bis(4-methoxyphenyl-2-[(1-methylpiperazin-4-yl)carbonyl]thiazole, Hydrochloride, 1-[(4,5-Bis(4-methoxyphenyl-2-thiazoyl)carbonyl]-4-methylpiperazine, Hydrochloride
Chemical Properties
Molecular Weight459.99
FormulaC23H26ClN3O3S
Cas No.130717-51-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 4 mg/mL(8.70 mM)
H2O: 2 mg/mL(4.35 mM)
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.1740 mL10.8698 mL21.7396 mL108.6980 mL
DMSO
1mg5mg10mg50mg
5 mM0.4348 mL2.1740 mL4.3479 mL21.7396 mL
10 mM0.2174 mL1.0870 mL2.1740 mL10.8698 mL
20 mM0.1087 mL0.5435 mL1.0870 mL5.4349 mL
50 mM0.0435 mL0.2174 mL0.4348 mL2.1740 mL
100 mM0.0217 mL0.1087 mL0.2174 mL1.0870 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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