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Garcinol

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Catalog No. T11366Cas No. 78824-30-3

Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively.

Garcinol

Garcinol

😃Good
Purity: 98.59%
Catalog No. T11366Cas No. 78824-30-3
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively.
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1 mg$148Backorder
5 mg$387Backorder
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1 mL x 10 mM (in DMSO)$458In Stock
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Purity:98.59%
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Product Introduction

Bioactivity
Description
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively.
Targets&IC50
BChE:7.39 µM , AChE:0.66 µM
In vitro
Garcinol (10-50 μM; 24-72 hours) induces apoptosis and inhibits the proliferation of HNSCC cells in a time- and dose-dependent manner, specifically in the cell lines CAL27 and UMSCC1. Additionally, Garcinol (50 μM; 1-6 hours) suppresses the phosphorylation and degradation of constitutive IκBα in a time-dependent manner.
In vivo
Garcinolinduces significant inhibition of tumor growth.
Chemical Properties
Molecular Weight602.8
FormulaC38H50O6
Cas No.78824-30-3
SmilesCC(C)=CC[C@@H](C[C@@]12C[C@@H](CC=C(C)C)C(C)(C)[C@@](CC=C(C)C)(C(=O)C(C(=O)c3ccc(O)c(O)c3)=C1O)C2=O)C(C)=C
Relative Density.1.114 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 20 mg/mL (33.18 mM), Sonication and heating are recommended.
DMSO: 20 mg/mL (33.18 mM), Sonication and heating are recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM1.6589 mL8.2946 mL16.5893 mL82.9463 mL
5 mM0.3318 mL1.6589 mL3.3179 mL16.5893 mL
10 mM0.1659 mL0.8295 mL1.6589 mL8.2946 mL
20 mM0.0829 mL0.4147 mL0.8295 mL4.1473 mL

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