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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $166 | In Stock | |
5 mg | $365 | In Stock |
Description | Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM). |
In vitro | Glaucocalyxin A (GlnA) and (GlnB) dose-dependently decrease the growth of HL-60 cells (IC50s: 6.15 and 5.86 μM at 24 h). Both Gln A and B could induce apoptosis, G2/M-phase cycle arrest, DNA damage and the accumulation of reactive oxygen species (ROS) in HL-60 cells[1]. GlnB inhibits the proliferation of human cervical cancer cells in vitro through the induction of apoptosis and autophagy, which may be mediated by the phosphatidylinositol 4,5 bisphosphate 3 kinase/Akt signaling pathway. Treatment with GlnB inhibits the proliferation of HeLa and SiHa cervical cancer cell lines in a dose-dependent manner. GlnB increases the apoptotic cell population and enhanced poly (ADP ribose) polymerase 1 cleavage [2]. |
Cell Research | The microglia cell viability is assessed by MTT assay. Cells are seeded in 96-well plates at the density of 5 × 10^4 cells/well. The cell culture supernatant is discarded after treatment with various agents, and then 30 μL of MTT (0.5 mg/mL) solution is added into each well. After incubation for 4 h at 37 °C, 100 μL of DMSO is added into each well to dissolve the formazan dye, and then the absorbance of solubilized formazan is measured by microplate reader [3]. |
Molecular Weight | 374.47 |
Formula | C22H30O5 |
Cas No. | 80508-81-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMSO: Soluble |
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