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GNE-8324
🥰Excellent
Catalog No. T31981Cas No. 1698901-76-6
Alias GNE8324, GNE 8324
GNE-8324 is a GluN2A selective positive allosteric modulator that selectively enhances NMDAR-mediated synaptic responses in inhibitory, but not excitatory, neurons.GNE-8324 is used in the study of neurological disorders.
GNE-8324
🥰Excellent
Purity: 99.34%
Catalog No. T31981Alias GNE8324, GNE 8324Cas No. 1698901-76-6
GNE-8324 is a GluN2A selective positive allosteric modulator that selectively enhances NMDAR-mediated synaptic responses in inhibitory, but not excitatory, neurons.GNE-8324 is used in the study of neurological disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 100 mg | $2,500 | In Stock |
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Purity:99.34%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | GNE-8324 is a GluN2A selective positive allosteric modulator that selectively enhances NMDAR-mediated synaptic responses in inhibitory, but not excitatory, neurons.GNE-8324 is used in the study of neurological disorders. |
| In vitro | At GluN2A-type NMDARs, there is a reciprocal allosteric interaction between the binding sites for GNE-8324 and glutamate, meaning that glutamate binding promotes the binding of GNE-8324, and vice versa. GNE-8324 selectively enhances NMDARs containing the GluN2A subunit, with its potentiating effect significantly dependent on the occupancy of the glutamate site. The binding affinity of GNE-8324 is markedly higher in glutamate-bound NMDARs compared to those without bound glutamate. [1] |
| Alias | GNE8324, GNE 8324 |
| Molecular Weight | 343.42 |
| Formula | C18H18FN3OS |
| Cas No. | 1698901-76-6 |
| Smiles | O=C1C=C(N=C2SC3=C(N12)CCC3)CN(C4=CC=C(F)C=C4)CC |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (232.95 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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