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GNF351

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Purity:99.04%

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COA HPLC HNMR

GNF351

Catalog No. T15410Cas No. 1227634-69-6

GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).

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Pack Size	Price	Availability
1 mg	$37	In Stock
5 mg	$86	In Stock
10 mg	$147	In Stock
25 mg	$297	In Stock
50 mg	$547	In Stock
100 mg	$736	In Stock
200 mg	$995	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock

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Product Introduction

Bioactivity

Description	GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM).
In vitro	After treating proliferating monolayer cultures of human keratinocytes, GNF351 (500 nM, 48 hours) obviously decreases the percentage of Ki67-positive cells and cell number.

Chemical Properties

Molecular Weight	411.5
Formula	C24H25N7
Cas No.	1227634-69-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 124 mg/mL(301.34 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4301 mL	12.1507 mL	24.3013 mL	121.5067 mL
5 mM	0.4860 mL	2.4301 mL	4.8603 mL	24.3013 mL
10 mM	0.2430 mL	1.2151 mL	2.4301 mL	12.1507 mL
20 mM	0.1215 mL	0.6075 mL	1.2151 mL	6.0753 mL
50 mM	0.0486 mL	0.2430 mL	0.4860 mL	2.4301 mL
100 mM	0.0243 mL	0.1215 mL	0.2430 mL	1.2151 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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