Shopping Cart
- Remove All
- Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $34 | In Stock | |
2 mg | $48 | In Stock | |
5 mg | $85 | In Stock | |
10 mg | $130 | In Stock | |
25 mg | $265 | In Stock | |
50 mg | $389 | In Stock | |
100 mg | $556 | In Stock | |
200 mg | $758 | In Stock | |
1 mL x 10 mM (in DMSO) | $118 | In Stock |
Description | GRA Ex-25 (GRA-Ex-25) is an inhibitor of glucagon receptor. |
Targets&IC50 | Glucagon (rat):56nM, Glucagon (human):55 nM |
In vitro | GRA Ex-25 binds to the human glucagon receptor (h-GlucRbind) with a Ki of 63 nM and exhibits moderate glucagon-induced adenylate cyclase inhibition (h-GlucRcyclase) with a Ki of 254 nM under our assay conditions[1], showing similar affinity for both rat and human glucagon receptors (IC50=56 and 55 nM, respectively)[2]. |
In vivo | GRA Ex-25 (3 mg/kg, i.v.) significantly reduces blood glucose induced by exogenous glucagon in rat models, likely through direct inhibition of glucagon-stimulated hepatic glucose output[2]. |
Alias | GRA-Ex-25 |
Molecular Weight | 563.61 |
Formula | C29H36F3N3O5 |
Cas No. | 307983-31-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (88.71 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.