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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $448 | In Stock | |
10 mg | $658 | In Stock | |
25 mg | $987 | In Stock | |
50 mg | $1,380 | In Stock | |
100 mg | $1,890 | In Stock | |
500 mg | $3,780 | In Stock | |
1 mL x 10 mM (in DMSO) | $668 | In Stock |
Description | GRGDSPK acetate shows inhibitory activity against integrin-fibronectin binding and can be used in research on integrins in bone formation and resorption. |
In vitro | By measuring calcium content and 70 bonehnit area of tissue in parietal bones 18 days old isolated from pregnant Sprague-Dawley rats, we know that GRGDSPK (EMD 56574; RGD; 0.1-50 μM; for 4 days) inhibits mineralization in a dose-dependent manner.[1] Treatment with GRGDSPK (10 and 50 μM; 4-day treatment) results in significant alterations in bone morphology, characterized by disruptions in the organization of osteoblasts and the mineralized matrix.[1] In the presence of GRGDSPK peptide (RGD; 250 μM), added to the medium, the binding between integrins and fibronectin is effectively blocked, leading to a considerable increase in the average size of cell aggregates in wild-type cells.[2] Addition of GRGDSPK (250 μM) leads to a significant reduction in adhesion forces and work exerted by wild-type mesendodermal progenitors, indicating the involvement of integrins expressed in these progenitors and the specificity of the detachment parameters recorded for fibronectin.[2] GRGDSPK (RGD-containing, 1.5 mM, 1.0 mM, and 0.5 mM) and RGD-modified peptides, at concentrations of 1.5 mM, 1.0 mM, and 0.5 mM, impair the fertilization ability of bovine oocytes by sperm cells, resulting in a dose-dependent reduction in cleavage rates.[3] |
Alias | GRGDSPK acetate(111119-28-9 Free base) |
Molecular Weight | 775.81 |
Formula | C30H53N11O13 |
Cas No. | 144027-77-0 |
Storage | store at low temperature,keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
Solubility Information | DMSO: 7.76 mg/mL (10 mM) ![]() | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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