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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $71 | In Stock | |
5 mg | $166 | In Stock | |
10 mg | $291 | In Stock | |
25 mg | $488 | In Stock | |
50 mg | $715 | In Stock | |
100 mg | $987 | In Stock |
Description | GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy. |
In vivo | GSK-3β inhibitor 1(compound 3a) inhibits GSK-3β with IC50 4.19 nM. In a cell-based assay 3a shows no significant leucocyte toxicity at 10 M and is moderately cytotoxic against A549 cells. Compound 3a demonstrated high antidiabetic efficacy in obese streptozotocin-treated rats improving glucose tolerance at a dose of 50 mg/kg body weight thus representing an interesting lead for further optimization. |
Molecular Weight | 222.24 |
Formula | C14H10N2O |
Cas No. | 187325-53-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (134.99 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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