Shopping Cart

Remove All

Your shopping cart is currently empty

GSK620

Select Batch

Purity:99.88%

Resource Download

COA HPLC HNMR

GSK620

Catalog No. T9020Cas No. 2088410-46-0

GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 shows an anti-inflammatory phenotype in human whole blood.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$33	In Stock
5 mg	$76	In Stock
10 mg	$122	In Stock
25 mg	$247	In Stock
50 mg	$396	In Stock
100 mg	$589	In Stock
500 mg	$1,280	In Stock
1 mL x 10 mM (in DMSO)	$84	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "GSK620"

Product Introduction

Bioactivity

Description

In vitro

GSK620 showed an anti-inflammatory phenotype in human whole blood, confirming it cellular target engagement.?Human blood samples are stimulated with LPS, which produces a strong immune response. The monocyte chemattractant protein 1 (MCP-1/CCL2) is measured. This is a chemokine which recruits monocytes, memory T cells, and dendritic cells to sites of inflammation. GSK620 reduces the MCP-1 response in a concentration-dependent manner with (an expected) ～1 log drop off in potency relative to the biochemical BRD4 BD2 potencies observed

Chemical Properties

Molecular Weight	325.36
Formula	C18H19N3O3
Cas No.	2088410-46-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (138.31 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0735 mL	15.3676 mL	30.7352 mL	153.6759 mL
5 mM	0.6147 mL	3.0735 mL	6.1470 mL	30.7352 mL
10 mM	0.3074 mL	1.5368 mL	3.0735 mL	15.3676 mL
20 mM	0.1537 mL	0.7684 mL	1.5368 mL	7.6838 mL
50 mM	0.0615 mL	0.3074 mL	0.6147 mL	3.0735 mL
100 mM	0.0307 mL	0.1537 mL	0.3074 mL	1.5368 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc