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Guanidinosuccinic acid
🥰Excellent
Catalog No. T7523Cas No. 6133-30-8
Guanidinosuccinic acid (GSA) has been identified as a uremic toxin, is a nitrogenous metabolite isolated in excess from serum and urine.
Guanidinosuccinic acid
🥰Excellent
Catalog No. T7523Cas No. 6133-30-8
Guanidinosuccinic acid (GSA) has been identified as a uremic toxin, is a nitrogenous metabolite isolated in excess from serum and urine.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $35 | In Stock | |
| 50 mg | $48 | In Stock | |
| 100 mg | $85 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Guanidinosuccinic acid (GSA) has been identified as a uremic toxin, is a nitrogenous metabolite isolated in excess from serum and urine. |
| In vivo | Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, was administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old.?Epileptogenic and toxic properties were assessed and GSA brain levels following i.p. injection were determined.?In adult mice, GSA induced long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD50 (and 95% confidence interval) of 363 (287-458) mg/kg (n = 35), and an LD50 of 579 (445-756) mg/kg.?The CD50 of GSA corresponded with a brain concentration of 56 nmol/g tissue.?Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions.?When young mice were i.p. injected with a (for adults) subconvulsive dose of GSA (250 mg/kg), an age-dependent decrease was noted in GSA-induced convulsions and in the resulting brain concentration[1]. |
| Molecular Weight | 175.14 |
| Formula | C5H9N3O4 |
| Cas No. | 6133-30-8 |
| Smiles | NC(=N)N[C@@H](CC(O)=O)C(O)=O |
| Relative Density. | 1.74g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 6 mg/mL (34.26 mM) DMSO: 75 mg/mL (428.23 mM) | ||||||||||||||||||||||||||||||||||||||||
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H2O/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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