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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $91 | In Stock | |
5 mg | $213 | In Stock | |
10 mg | $333 | In Stock | |
25 mg | $588 | In Stock | |
50 mg | $855 | In Stock | |
100 mg | $1,180 | In Stock | |
1 mL x 10 mM (in DMSO) | $235 | In Stock |
Description | HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22 nM), ULK2 (IC50: 63 nM), MAP4K5 (IC50. HS-276 can be used to study rheumatoid arthritis (RA). |
Targets&IC50 | GCK:33 nM, CSNK1G2:810 nM, CaMKK β1:1280 nM, TAK1:2.5 nM (Ki), CLK2:29 nM, NUAK:270 nM, TAK1:8.25 nM, IRAK1:264 nM, MAP4K5:125 nM, MLK1:5585 nM, ULK2:63 nM |
Molecular Weight | 419.52 |
Formula | C24H29N5O2 |
Cas No. | 2767422-72-8 |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45.0 mg/mL (107.3 mM), when pH is adjusted to 2 with HCl. Sonication and heating to 80℃ are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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