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IMD-0560

Catalog No. T15564Cas No. 439144-66-8

IMD-0560 is a novel inhibitor of IκB kinase β.

IMD-0560

IMD-0560

Purity: 99.51%
Catalog No. T15564Cas No. 439144-66-8
IMD-0560 is a novel inhibitor of IκB kinase β.
Pack SizePriceAvailabilityQuantity
1 mg$37In Stock
5 mg$88In Stock
10 mg$142In Stock
25 mg$257In Stock
50 mg$386In Stock
100 mg$530In Stock
200 mg$729In Stock
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Purity:99.51%
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Product Introduction

Bioactivity
Description
IMD-0560 is a novel inhibitor of IκB kinase β.
In vitro
IMD-0560 inhibits TNFα-caused transcriptional activity. Pretreatment with IMD-0560 suppresses both IκBα degradation and p65 phosphorylation induced by TNFα and also strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression.
In vivo
Compare to the control groups, zygoma destruction is obviously suppressed in the IMD-0560-treated groups. In the IMD-0560-treated groups, the tumor size is decreased in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. The inhibitory effect of each treatment on zygoma destruction is similar, although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group.
Chemical Properties
Molecular Weight428.12
FormulaC15H8BrF6NO2
Cas No.439144-66-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 50 mg/mL (116.79 mM), Sonication is recommended.
Solution Preparation Table
Ethanol
1mg5mg10mg50mg
1 mM2.3358 mL11.6790 mL23.3579 mL116.7897 mL
5 mM0.4672 mL2.3358 mL4.6716 mL23.3579 mL
10 mM0.2336 mL1.1679 mL2.3358 mL11.6790 mL
20 mM0.1168 mL0.5839 mL1.1679 mL5.8395 mL
50 mM0.0467 mL0.2336 mL0.4672 mL2.3358 mL
100 mM0.0234 mL0.1168 mL0.2336 mL1.1679 mL

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