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IMD-0560

IMD-0560
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Purity:99.78%
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IMD-0560

Catalog No. T15564Cas No. 439144-66-8
IMD-0560 is a novel inhibitor of IκB kinase β.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$61In Stock
5 mg$147In Stock
10 mg$237In Stock
25 mg$428In Stock
50 mg$643In Stock
100 mg$883In Stock
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Product Introduction

Bioactivity
Description
IMD-0560 is a novel inhibitor of IκB kinase β.
In vitro
IMD-0560 inhibits TNFα-caused transcriptional activity. Pretreatment with IMD-0560 suppresses both IκBα degradation and p65 phosphorylation induced by TNFα and also strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression.
In vivo
Compare to the control groups, zygoma destruction is obviously suppressed in the IMD-0560-treated groups. In the IMD-0560-treated groups, the tumor size is decreased in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. The inhibitory effect of each treatment on zygoma destruction is similar, although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group.
Chemical Properties
Molecular Weight428.12
FormulaC15H8BrF6NO2
Cas No.439144-66-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 50 mg/mL (116.79 mM), Sonication is recommended.
Solution Preparation Table
Ethanol
1mg5mg10mg50mg
1 mM2.3358 mL11.6790 mL23.3579 mL116.7897 mL
5 mM0.4672 mL2.3358 mL4.6716 mL23.3579 mL
10 mM0.2336 mL1.1679 mL2.3358 mL11.6790 mL
20 mM0.1168 mL0.5839 mL1.1679 mL5.8395 mL
50 mM0.0467 mL0.2336 mL0.4672 mL2.3358 mL
100 mM0.0234 mL0.1168 mL0.2336 mL1.1679 mL

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