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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $61 | In Stock | |
5 mg | $147 | In Stock | |
10 mg | $237 | In Stock | |
25 mg | $428 | In Stock | |
50 mg | $643 | In Stock | |
100 mg | $883 | In Stock |
Description | IMD-0560 is a novel inhibitor of IκB kinase β. |
In vitro | IMD-0560 inhibits TNFα-caused transcriptional activity. Pretreatment with IMD-0560 suppresses both IκBα degradation and p65 phosphorylation induced by TNFα and also strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression. |
In vivo | Compare to the control groups, zygoma destruction is obviously suppressed in the IMD-0560-treated groups. In the IMD-0560-treated groups, the tumor size is decreased in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. The inhibitory effect of each treatment on zygoma destruction is similar, although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group. |
Molecular Weight | 428.12 |
Formula | C15H8BrF6NO2 |
Cas No. | 439144-66-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 50 mg/mL (116.79 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol
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