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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $215 | In Stock | |
2 mg | $318 | In Stock | |
5 mg | $538 | In Stock | |
10 mg | $823 | In Stock | |
25 mg | $1,580 | In Stock | |
50 mg | $1,980 | In Stock | |
100 mg | $2,500 | In Stock |
Description | JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively. |
Targets&IC50 | JAK2 (V617F):109 nM, JAK2:2.04 nM, JAK1:1.73 nM, TYK2:62.9 nM |
In vitro | JAK-IN-21 (Example 4) exhibits no inhibitory effects on CYPs and shows favorable stability in liver microsomes.[1] |
In vivo | JAK-IN-21 (Example 4) (10 mg/kg; Oral gavage; SD rats) demonstrates limited bioavailability, quantified at 1.9%.[1] |
Molecular Weight | 372.38 |
Formula | C19H16N8O |
Cas No. | 2445499-20-5 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (161.13 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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