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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $49 | In Stock | |
2 mg | $75 | In Stock | |
5 mg | $109 | In Stock | |
10 mg | $135 | In Stock | |
25 mg | $298 | In Stock | |
50 mg | $433 | In Stock | |
100 mg | Inquiry | In Stock |
Description | JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM). JNJ 10191584 maleate inhibits chemotaxis of eosinophils and mast cells (IC50 = 530 nM and 138 nM). |
In vitro | JNJ 10191584 maleate shows 540-fold selectivity to H4 receptor(Ki = 14.1 μM)[2]. |
In vivo | In spared nerve injury mice, JNJ 10191584 maleate (10 μg/μL; intra locus coeruleus administration) abolishes VUF-induced anti-allodynic effect and prevents the anti-allodynic effect of VUF 8430. JNJ 10191584 maleate (6 μg/mouse; intrathecal administration) prevents VUF 8430-induced anti-allodynic effect[2]. |
Alias | JNJ 10191584 maleate salt, VUF6002 maleate |
Molecular Weight | 394.81 |
Formula | C17H19ClN4O5 |
Cas No. | 869497-75-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 18 mg/mL (45.6 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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