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JNJ 10191584 maleate

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Purity:99.82%

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COA HPLC HNMR

JNJ 10191584 maleate

Catalog No. T22879Cas No. 869497-75-6

JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM). JNJ 10191584 maleate inhibits chemotaxis of eosinophils and mast cells (IC50 = 530 nM and 138 nM).

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Pack Size	Price	Availability
1 mg	$49	In Stock
2 mg	$75	In Stock
5 mg	$109	In Stock
10 mg	$135	In Stock
25 mg	$298	In Stock
50 mg	$433	In Stock
100 mg	Inquiry	In Stock

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Product Introduction

Bioactivity

Description	JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM). JNJ 10191584 maleate inhibits chemotaxis of eosinophils and mast cells (IC50 = 530 nM and 138 nM).
In vitro	JNJ 10191584 maleate shows 540-fold selectivity to H4 receptor(Ki = 14.1 μM)[2].
In vivo	In spared nerve injury mice, JNJ 10191584 maleate (10 μg/μL; intra locus coeruleus administration) abolishes VUF-induced anti-allodynic effect and prevents the anti-allodynic effect of VUF 8430. JNJ 10191584 maleate (6 μg/mouse; intrathecal administration) prevents VUF 8430-induced anti-allodynic effect[2].
Alias	JNJ 10191584 maleate salt, VUF6002 maleate

Chemical Properties

Molecular Weight	394.81
Formula	C17H19ClN4O5
Cas No.	869497-75-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 18 mg/mL (45.6 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5329 mL	12.6643 mL	25.3286 mL	126.6432 mL
5 mM	0.5066 mL	2.5329 mL	5.0657 mL	25.3286 mL
10 mM	0.2533 mL	1.2664 mL	2.5329 mL	12.6643 mL
20 mM	0.1266 mL	0.6332 mL	1.2664 mL	6.3322 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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