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JNJ 10191584 maleate
Catalog No. T22879Cas No. 869497-75-6
Alias VUF6002 maleate, JNJ 10191584 maleate salt
JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM). JNJ 10191584 maleate inhibits chemotaxis of eosinophils and mast cells (IC50 = 530 nM and 138 nM).
JNJ 10191584 maleate
Catalog No. T22879Alias VUF6002 maleate, JNJ 10191584 maleate saltCas No. 869497-75-6
JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM). JNJ 10191584 maleate inhibits chemotaxis of eosinophils and mast cells (IC50 = 530 nM and 138 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $49 | In Stock | |
| 2 mg | $75 | In Stock | |
| 5 mg | $109 | In Stock | |
| 10 mg | $135 | In Stock | |
| 25 mg | $298 | In Stock | |
| 50 mg | $433 | In Stock | |
| 100 mg | Inquiry | In Stock |
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Purity:99.82%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | JNJ 10191584 maleate (VUF6002 maleate) is an orally active and selective antagonist of H4 receptor (Ki = 26 nM). JNJ 10191584 maleate inhibits chemotaxis of eosinophils and mast cells (IC50 = 530 nM and 138 nM). |
| In vitro | JNJ 10191584 maleate shows 540-fold selectivity to H4 receptor(Ki = 14.1 μM)[2]. |
| In vivo | In spared nerve injury mice, JNJ 10191584 maleate (10 μg/μL; intra locus coeruleus administration) abolishes VUF-induced anti-allodynic effect and prevents the anti-allodynic effect of VUF 8430. JNJ 10191584 maleate (6 μg/mouse; intrathecal administration) prevents VUF 8430-induced anti-allodynic effect[2]. |
| Alias | VUF6002 maleate, JNJ 10191584 maleate salt |
| Molecular Weight | 394.81 |
| Formula | C17H19ClN4O5 |
| Cas No. | 869497-75-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 18 mg/mL (45.6 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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