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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $84 | In Stock | |
5 mg | $198 | In Stock | |
10 mg | $313 | In Stock | |
25 mg | $533 | In Stock | |
50 mg | $768 | In Stock | |
100 mg | $1,080 | In Stock | |
1 mL x 10 mM (in DMSO) | $226 | In Stock |
Description | JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor. |
In vitro | In vitro, thiophene compounds potently inhibited intracellular Ca2+ release in human macrophages without inhibiting the agonist effects in the same concentration range as the related Complement protein C5a[1]. |
In vivo | JR14a reduces mast cell degranulation and macrophage infiltration in BR103-induced rat paw edema[1]. |
Alias | 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride |
Molecular Weight | 533.47 |
Formula | C25H26Cl2N4O3S |
Cas No. | 2411440-41-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90 mg/mL (168.71 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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