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JR14a
🥰Excellent
Catalog No. T9316Cas No. 2411440-41-8
Alias 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride
JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor.
JR14a
🥰Excellent
Purity: 99.29%
Catalog No. T9316Alias 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochlorideCas No. 2411440-41-8
JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $84 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $313 | In Stock | |
| 25 mg | $533 | In Stock | |
| 50 mg | $768 | In Stock | |
| 100 mg | $1,080 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $226 | In Stock |
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Purity:99.29%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor. |
| In vitro | In vitro, thiophene compounds potently inhibited intracellular Ca2+ release in human macrophages without inhibiting the agonist effects in the same concentration range as the related Complement protein C5a[1]. |
| In vivo | JR14a reduces mast cell degranulation and macrophage infiltration in BR103-induced rat paw edema[1]. |
| Alias | 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride |
| Molecular Weight | 533.47 |
| Formula | C25H26Cl2N4O3S |
| Cas No. | 2411440-41-8 |
| Smiles | Cc1cc(sc1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 |
| Relative Density. | 1.41 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90 mg/mL (168.71 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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