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Karacoline

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Purity:99.75%

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COA HNMR HPLC

Karacoline

Catalog No. TN1833Cas No. 39089-30-0

Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway.

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Pack Size	Price	Availability
1 mg	$177	In Stock
5 mg	$378	In Stock
10 mg	$563	In Stock
25 mg	$888	In Stock
50 mg	$1,230	In Stock
100 mg	$1,670	In Stock
1 mL x 10 mM (in DMSO)	$427	In Stock

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Related Compound Libraries of "Karacoline"

Product Introduction

Bioactivity

Description

Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway.

In vitro

From the ethanol extract, six feeding deterrents were isolated by bioassay-guided fractionation. The compounds were identified as chasmanine, crassicauline A, Karacoline, sachaconitine, talatisamine, and yunaconitine from their spectroscopic data. Chasmanine, talatisamine, Karacoline, and sachaconitine exhibited feeding deterrent activity against T. castaneum adults, with EC(50) values of 297.0, 342.8, 395.3, and 427.8 ppm, respectively. Yunaconitine and crassicauline A also possessed feeding deterrent activity against T. castaneum adults, with EC(50) values of 653.4 and 1134.5 ppm, respectively.

Chemical Properties

Molecular Weight	377.52
Formula	C22H35NO4
Cas No.	39089-30-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/ml (79.47 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6489 mL	13.2443 mL	26.4887 mL	132.4433 mL
5 mM	0.5298 mL	2.6489 mL	5.2977 mL	26.4887 mL
10 mM	0.2649 mL	1.3244 mL	2.6489 mL	13.2443 mL
20 mM	0.1324 mL	0.6622 mL	1.3244 mL	6.6222 mL
50 mM	0.0530 mL	0.2649 mL	0.5298 mL	2.6489 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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