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KL-11743
🥰Excellent
Catalog No. T9558Cas No. 1369452-53-8
KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria.
KL-11743
🥰Excellent
Purity: 98.12%
Catalog No. T9558Cas No. 1369452-53-8
KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $115 | In Stock | |
| 5 mg | $247 | In Stock | |
| 10 mg | $397 | In Stock | |
| 25 mg | $663 | In Stock | |
| 50 mg | $945 | In Stock | |
| 100 mg | $1,280 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $283 | In Stock |
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CitedSelect Batch
Purity:98.12%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria. |
| Targets&IC50 | GLUT2:137 nM (IC50), GLUT1:115 nM (IC50), GLUT3:90 nM (IC50), GLUT4:68 nM (IC50) |
| In vitro | Patient-derived xenograft models of succinate dehydrogenase A (SDHA)-deficient cancers are specifically sensitive to KL-11743, providing direct evidence that TCA cycle-mutant tumors are vulnerable to GLUT inhibitors in vivo[1]. |
| Molecular Weight | 522.6 |
| Formula | C30H30N6O3 |
| Cas No. | 1369452-53-8 |
| Smiles | CCOc1ccc2nc(nc(Nc3ccc(cc3)-c3cn[nH]c3)c2c1)-c1cccc(OCC(=O)NC(C)C)c1 |
| Relative Density. | 1.259 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (47.84 mM)  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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