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L-Cysteinesulfinic acid monohydrate

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Catalog No. T41301Cas No. 207121-48-0

L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively [1].

L-Cysteinesulfinic acid monohydrate

L-Cysteinesulfinic acid monohydrate

🥰Excellent
Catalog No. T41301Cas No. 207121-48-0
L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively [1].
Pack SizePriceAvailabilityQuantity
10 mg$31In Stock
25 mg$56In Stock
50 mg$93In Stock
100 mg$147In Stock
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Purity:≥98%
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Product Introduction

Bioactivity
Description
L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively [1].
In vitro
L-Cysteinesulfinic acid (monohydrate) serves as an innate activator for the phospholipase D (PLD)-linked metabotropic excitatory amino acids (EAA) receptor, selectively triggering the PLD-associated mechanism. When applied to hippocampal slices, 1 mM concentrations of L-CSA (monohydrate) significantly enhance PLD activity, unlike similar doses of L-glutamate, L-aspartate, and L-HCA, which show no effect. Furthermore, L-CSA (monohydrate) prompts a dose-responsive elevation in PLD activity in these slices, even when iGluR antagonists are present, with the potency around an EC50 of 500 uM. Notably, the response to 1 mM L-CSA (monohydrate) in augmenting PLD activity remains unaltered by 1 uM tetrodotoxin, indicating that the effect is not reliant on an increase in neuronal activity[1].
Chemical Properties
Molecular Weight171.17
FormulaC3H9NO5S
Cas No.207121-48-0
SmilesO.N[C@@H](CS(O)=O)C(O)=O
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 120 mg/mL (701.06 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM5.8421 mL29.2107 mL58.4215 mL292.1073 mL
5 mM1.1684 mL5.8421 mL11.6843 mL58.4215 mL
10 mM0.5842 mL2.9211 mL5.8421 mL29.2107 mL
20 mM0.2921 mL1.4605 mL2.9211 mL14.6054 mL
50 mM0.1168 mL0.5842 mL1.1684 mL5.8421 mL
100 mM0.0584 mL0.2921 mL0.5842 mL2.9211 mL

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