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Lauric Acid

🥰Excellent
Catalog No. T6873Cas No. 143-07-7
Alias N-Dodecanoic acid, Dodecylic acid, dodecanoic acid

Lauric Acid (Dodecylic acid),which is found naturally in various plant and animal fats and oils, is a saturated medium-chain fatty acid with a 12-carbon backbone. It is a major component of coconut oil and palm kernel oil.

Lauric Acid

Lauric Acid

🥰Excellent
Purity: 99.95%
Catalog No. T6873Alias N-Dodecanoic acid, Dodecylic acid, dodecanoic acidCas No. 143-07-7
Lauric Acid (Dodecylic acid),which is found naturally in various plant and animal fats and oils, is a saturated medium-chain fatty acid with a 12-carbon backbone. It is a major component of coconut oil and palm kernel oil.
Pack SizePriceAvailabilityQuantity
500 mg43 €In Stock
1 g52 €In Stock
1 mL x 10 mM (in DMSO)47 €In Stock
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Purity:99.95%
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Product Introduction

Bioactivity
Description
Lauric Acid (Dodecylic acid),which is found naturally in various plant and animal fats and oils, is a saturated medium-chain fatty acid with a 12-carbon backbone. It is a major component of coconut oil and palm kernel oil.
Targets&IC50
S. epidermidis:4 μg/mL(EC50), S. aureus:6μg/mL(EC50), P. acnes:2μg/mL(EC50)
In vitro
Lauric acid induces apoptosis in Caco-2 (p<0.05) and IEC-6 cells (p<0.05). In Caco-2 cells, lauric acid reduces GSH availability and generated ROS compared to butyrate(p < 0.05). Lauric acid reduces Caco-2 and IEC-6 cells in G0/G1 and arrested cells in the S and G2/M phases. Lauric acid induces apoptosis in IEC-6 cells compared to butyrate(p < 0.05). Lauric acid induces high levels of ROS[1].
Kinase Assay
JAK2 and other human kinase activity assays: JAK2 kinase activity was assessed with the HTScan JAK2 Kinase Assay Kit per manufacturer's protocol. The possible effects of FLLL32 on the other 10 purified human protein kinases were determined by using a Kinase Profiler Assay.
Cell Research
Cell lines are harvested by enzymatic dissociation and seeded into 24-well tissue culture plates at 2.5 × 105 and 1.5 × 105 cells/ml, respectively. After 24 h of incubation, the medium is replaced with 1 ml of complete DMEM containing freshly prepared (50 mM )Lauric acid, conjugated to 0.4% FAF-BSA to final concentrations of 0.1, 0.3, 0.5 and 1 mM and compared to NaB (5 mM ) with 50 μl of 0.4% FAF-BSA as a vehicle control and incubated in a humidified atmosphere at 37℃ in 5% CO2 and, after enzymatic dissociation, assayed at 24, 48, 72, and 96 h. All experimental studies are undertaken in triplicate and measured in duplicate. (Only for Reference)
AliasN-Dodecanoic acid, Dodecylic acid, dodecanoic acid
Chemical Properties
Molecular Weight200.32
FormulaC12H24O2
Cas No.143-07-7
SmilesCCCCCCCCCCCC(O)=O
Relative Density.0.883 g/cm3 at 25℃ (lit.)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 38 mg/mL (189.7 mM)
DMSO: 45 mg/mL (224.64 mM)
H2O: 16 mg/mL (79.9 mM)
Solution Preparation Table
H2O/Ethanol/DMSO
1mg5mg10mg50mg
1 mM4.9920 mL24.9601 mL49.9201 mL249.6006 mL
5 mM0.9984 mL4.9920 mL9.9840 mL49.9201 mL
10 mM0.4992 mL2.4960 mL4.9920 mL24.9601 mL
20 mM0.2496 mL1.2480 mL2.4960 mL12.4800 mL
50 mM0.0998 mL0.4992 mL0.9984 mL4.9920 mL
Ethanol/DMSO
1mg5mg10mg50mg
100 mM0.0499 mL0.2496 mL0.4992 mL2.4960 mL

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