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Leptomerine

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Catalog No. TN1858Cas No. 22048-97-1

Leptomerine is an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae). Leptomerine shows as anticholinesterasic activity and can be used in Alzheimer Disease studies.

Leptomerine

Leptomerine

🥰Excellent
Purity: 99.96%
Catalog No. TN1858Cas No. 22048-97-1
Leptomerine is an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae). Leptomerine shows as anticholinesterasic activity and can be used in Alzheimer Disease studies.
Pack SizePriceAvailabilityQuantity
1 mg$82In Stock
5 mg$166In Stock
10 mg$280In Stock
25 mg$460In Stock
50 mg$642In Stock
100 mg$870In Stock
200 mg$1,170In Stock
1 mL x 10 mM (in DMSO)$153In Stock
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Purity:99.96%
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Product Introduction

Bioactivity
Description
Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity.
Targets&IC50
AChE:2.5 mM
In vitro
Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, Leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid Leptomerine showed the highest activity (IC50 = 2.5 mM), similar to that of the reference compound galanthamine (IC50 = 1.7 mM).
Chemical Properties
Molecular Weight201.26
FormulaC13H15NO
Cas No.22048-97-1
SmilesCN1C=2C(C(=O)C=C1CCC)=CC=CC2
Relative Density.1.063 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 9 mg/mL (44.72 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.9687 mL24.8435 mL49.6870 mL248.4349 mL
5 mM0.9937 mL4.9687 mL9.9374 mL49.6870 mL
10 mM0.4969 mL2.4843 mL4.9687 mL24.8435 mL
20 mM0.2484 mL1.2422 mL2.4843 mL12.4217 mL

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