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MAP4K4-IN-3

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Purity:99.5%

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COA HNMR HPLC

MAP4K4-IN-3

Catalog No. T11942Cas No. 1811510-58-3

MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.

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Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$72	In Stock
25 mg	$155	In Stock
50 mg	$247	In Stock
100 mg	$393	In Stock
200 mg	$582	In Stock
500 mg	$885	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description	MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.
In vitro	MAP4K4-IN-3, Antidiabetic agent.MAP4K4-IN-3 is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay.
In vivo	Administering MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) orally to telemetered rats over a period of five days induces several adverse reactions. Cardiovascular measurements reveal a significant increase in maximal heart rate by 25 beats per minute (bpm) compared to control groups upon treatment with MAP4K4-IN-3[2]. Additionally, there are noticeable declines in body weight (7%) and an increase in body temperature (0.4°C) against control values throughout the study.
Alias	Compound 17

Chemical Properties

Molecular Weight	297.74
Formula	C15H12ClN5
Cas No.	1811510-58-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 8 mg/mL (26.87 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3586 mL	16.7932 mL	33.5864 mL	167.9318 mL
5 mM	0.6717 mL	3.3586 mL	6.7173 mL	33.5864 mL
10 mM	0.3359 mL	1.6793 mL	3.3586 mL	16.7932 mL
20 mM	0.1679 mL	0.8397 mL	1.6793 mL	8.3966 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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