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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $39 | In Stock | |
25 mg | $80 | In Stock | |
50 mg | $128 | In Stock | |
100 mg | $193 | In Stock | |
200 mg | $287 | In Stock | |
500 mg | $486 | In Stock | |
1 mL x 10 mM (in DMSO) | $39 | In Stock |
Description | Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant. |
In vitro | Methotrexate metabolite was the most active, with 50% inhibitory concentrations in vitro of 446 ng/ml against the antifolate-sensitive strain and 812 ng/ml against the highly resistant strain under physiological folate conditions. Methotrexate metabolite potentiates the activity of the sulfone dapsone, an inhibitor of dihydropteroate synthase, but not that of chlorcycloguanil, a known inhibitor of dihydrofolate reductase (DHFR)[2]. |
Alias | DAMPA |
Molecular Weight | 325.33 |
Formula | C15H15N7O2 |
Cas No. | 19741-14-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 4 mg/mL (12.30 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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