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Methotrexate metabolite
🥰Excellent
Catalog No. T16045Cas No. 19741-14-1
Alias DAMPA
Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant.
Methotrexate metabolite
🥰Excellent
Purity: 99.7%
Catalog No. T16045Alias DAMPACas No. 19741-14-1
Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $48 | In Stock | |
| 50 mg | $77 | In Stock | |
| 100 mg | $116 | In Stock | |
| 500 mg | $292 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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CitedSelect Batch
Purity:99.7%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant. |
| In vitro | Methotrexate metabolite was the most active, with 50% inhibitory concentrations in vitro of 446 ng/ml against the antifolate-sensitive strain and 812 ng/ml against the highly resistant strain under physiological folate conditions. Methotrexate metabolite potentiates the activity of the sulfone dapsone, an inhibitor of dihydropteroate synthase, but not that of chlorcycloguanil, a known inhibitor of dihydrofolate reductase (DHFR)[2]. |
| Alias | DAMPA |
| Molecular Weight | 325.33 |
| Formula | C15H15N7O2 |
| Cas No. | 19741-14-1 |
| Smiles | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(O)=O |
| Relative Density. | 1.532g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (12.30 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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