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MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $58 | In Stock | |
5 mg | $118 | In Stock | |
10 mg | $198 | In Stock | |
25 mg | $375 | In Stock | |
50 mg | $563 | In Stock | |
100 mg | $768 | In Stock | |
1 mL x 10 mM (in DMSO) | $148 | In Stock |
Description | MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM). |
Targets&IC50 | Menin:6.5 nM(Kd), Menin-MLL:21 nM |
In vitro | Treatment with MI-538 results in strong down regulation of expression of Hoxa9 and Meis1 genes. About 100 nM 27 was sufficient to reduce by ~50% Hoxa9 expression in MLL-AF9 cells, and even more pronounced effect was seen on Meis1 expression. |
In vivo | Treatment with MI-538 leads to an approximately 80% reduction in MV4;11 tumor volume, with minimal toxicity, evidenced by less than a 10% decrease in body weight. |
Molecular Weight | 566.6 |
Formula | C27H25F3N8OS |
Cas No. | 1857417-10-7 |
Smiles | Oc1cc2n(Cc3cn[nH]c3)c(cc2cc1CN1CCC(CC1)Nc1ncnc2sc(CC(F)(F)F)cc12)C#N |
Relative Density. | 1.56 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 95 mg/mL (167.67 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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