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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $97 | In Stock | |
2 mg | $139 | In Stock | |
5 mg | $197 | In Stock | |
10 mg | $347 | In Stock | |
25 mg | $625 | In Stock | |
50 mg | $939 | In Stock | |
100 mg | $1,280 | In Stock | |
1 mL x 10 mM (in DMSO) | $246 | In Stock |
Description | MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM). |
Targets&IC50 | Menin-MLL:21 nM , Menin:6.5 nM(Kd) |
In vitro | Treatment with MI-538 results in strong down regulation of expression of Hoxa9 and Meis1 genes. About 100 nM 27 was sufficient to reduce by ~50% Hoxa9 expression in MLL-AF9 cells, and even more pronounced effect was seen on Meis1 expression. |
In vivo | Treatment with MI-538 leads to an approximately 80% reduction in MV4;11 tumor volume, with minimal toxicity, evidenced by less than a 10% decrease in body weight. |
Molecular Weight | 566.6 |
Formula | C27H25F3N8OS |
Cas No. | 1857417-10-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 95 mg/mL (167.67 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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