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Miglustat hydrochloride

Catalog No. TQ0155Cas No. 210110-90-0
Alias OGT918 hydrochloride, N-Butyldeoxynojirimycin hydrochloride, NB-DNJ hydrochloride

Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease.

Miglustat hydrochloride

Miglustat hydrochloride

Purity: 99.61%
Catalog No. TQ0155Alias OGT918 hydrochloride, N-Butyldeoxynojirimycin hydrochloride, NB-DNJ hydrochlorideCas No. 210110-90-0
Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease.
Pack SizePriceAvailabilityQuantity
1 mg$34In Stock
2 mg$48In Stock
5 mg$80In Stock
10 mg$143In Stock
25 mg$287In Stock
50 mg$497In Stock
100 mg$723In Stock
1 mL x 10 mM (in DMSO)$89In Stock
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Purity:99.61%
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Product Introduction

Bioactivity
Description
Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher disease.
In vivo
Consumption of a standard high-fat breakfast within 30 minutes before administration of Miglustat hydrochloride significantly reduced peak exposure but did not significantly affect the extent of systemic exposure to Miglustat hydrochloride. The Cmax decreased by 36% on average following administration with food. AUC showed a modest (14%) decrease with food, but the 90% confidence interval was within the acceptance limit of 80% to 125%. Tmax was prolonged from 2.5 (1.0-4.0) hours in the fasted state to 4.5 (1.5-8.0) hours in the fed state, whereas the apparent terminal half-life was approximately 8 hours and not affected by food[1].
AliasOGT918 hydrochloride, N-Butyldeoxynojirimycin hydrochloride, NB-DNJ hydrochloride
Chemical Properties
Molecular Weight255.74
FormulaC10H22ClNO4
Cas No.210110-90-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 34 mg/mL (132.95 mM)
DMSO: 60 mg/mL (234.61 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.9102 mL19.5511 mL39.1022 mL195.5111 mL
5 mM0.7820 mL3.9102 mL7.8204 mL39.1022 mL
10 mM0.3910 mL1.9551 mL3.9102 mL19.5511 mL
20 mM0.1955 mL0.9776 mL1.9551 mL9.7756 mL
50 mM0.0782 mL0.3910 mL0.7820 mL3.9102 mL
100 mM0.0391 mL0.1955 mL0.3910 mL1.9551 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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