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Minnelide is a water-soluble tretinoin lactone prodrug with anticancer and antitumor activity that induces apoptosis and may prevent podocyte damage.Minnelide inhibits cervical cancer growth by blocking HPV-induced changes in p53 and pRb.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $918 | 10-14 weeks | |
10 mg | $1,689 | 10-14 weeks | |
25 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks | |
100 mg | Inquiry | 10-14 weeks |
Description | Minnelide is a water-soluble tretinoin lactone prodrug with anticancer and antitumor activity that induces apoptosis and may prevent podocyte damage.Minnelide inhibits cervical cancer growth by blocking HPV-induced changes in p53 and pRb. |
In vitro | Minnelide (0.100 nM, 200 nM; 48 hours) decreased cell viability in vitro in the pancreatic cancer cell lines S2-013, MIA PaCa-2, S2-VP10, and Panc-1[2]. |
In vivo | In the orthotopic model of pancreatic cancer with MIA PaCa-2-derived human pancreatic tumors in athymic nude mice, Minnelide (0.1-0.6 mg/kg; intraperitoneal injection; once daily or twice daily) was able to inhibit pancreatic tumor growth in vivo[2]. |
Molecular Weight | 514.37 |
Formula | C21H25Na2O10P |
Cas No. | 1254702-87-8 |
Smiles | C[C@@]12[C@@]34[C@@]5([C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5)[C@@H]([C@@]7([C@](O7)([H])[C@]3([H])O4)C(C)C)OCOP([O-])([O-])=O.[Na+].[Na+] |
Relative Density. | no data available |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 10 mg/mL (19.44 mM), Sonication is recommended. H2O: 80 mg/mL (155.53 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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