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Minnelide

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Purity:98.49%

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COA HNMR LCMS

Minnelide

Catalog No. T12042Cas No. 1254702-87-8

Minnelide is a water-soluble tretinoin lactone prodrug with anticancer and antitumor activity that induces apoptosis and may prevent podocyte damage.Minnelide inhibits cervical cancer growth by blocking HPV-induced changes in p53 and pRb.

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Pack Size	Price	Availability
25 mg	$862	10-14 weeks
50 mg	$1,120	10-14 weeks
100 mg	$1,610	10-14 weeks

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Product Introduction

Bioactivity

Description	Minnelide is a water-soluble tretinoin lactone prodrug with anticancer and antitumor activity that induces apoptosis and may prevent podocyte damage.Minnelide inhibits cervical cancer growth by blocking HPV-induced changes in p53 and pRb.
In vitro	Minnelide (0.100 nM, 200 nM; 48 hours) decreased cell viability in vitro in the pancreatic cancer cell lines S2-013, MIA PaCa-2, S2-VP10, and Panc-1[2].
In vivo	In the orthotopic model of pancreatic cancer with MIA PaCa-2-derived human pancreatic tumors in athymic nude mice, Minnelide (0.1-0.6 mg/kg; intraperitoneal injection; once daily or twice daily) was able to inhibit pancreatic tumor growth in vivo[2].

Chemical Properties

Molecular Weight	514.37
Formula	C21H25Na2O10P
Cas No.	1254702-87-8

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (19.44 mM)

H2O: 80 mg/mL (155.53 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9441 mL	9.7206 mL	19.4413 mL	97.2063 mL
5 mM	0.3888 mL	1.9441 mL	3.8883 mL	19.4413 mL
10 mM	0.1944 mL	0.9721 mL	1.9441 mL	9.7206 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0972 mL	0.4860 mL	0.9721 mL	4.8603 mL
50 mM	0.0389 mL	0.1944 mL	0.3888 mL	1.9441 mL
100 mM	0.0194 mL	0.0972 mL	0.1944 mL	0.9721 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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