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ML-193

ML-193
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Purity:99.79%
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ML-193

Catalog No. T22103Cas No. 713121-80-3
ML-193 (CID 1261822) is a potent and selective GPR55 antagonist (IC50: 221 nM) with over 27-fold selectivity for GPR55 over GPR35, CB1, and CB2. It can ameliorate motor and sensorimotor deficits in Parkinson’s disease (PD) rats.
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Pack SizePriceAvailabilityQuantity
5 mg$39In Stock
10 mg$67In Stock
25 mg$112In Stock
50 mg$169In Stock
100 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$57In Stock
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Product Introduction

Bioactivity
Description
ML-193 (CID 1261822) is a potent and selective GPR55 antagonist (IC50: 221 nM) with over 27-fold selectivity for GPR55 over GPR35, CB1, and CB2. It can ameliorate motor and sensorimotor deficits in Parkinson’s disease (PD) rats.
Targets&IC50
GPR55:221 nM
In vitro
ML193, a selective GPR55 antagonist.?ML184 significantly promoted neuronal differentiation in vitro while ML193 reduced differentiation rates as compared to vehicle treatment.Continuous administration of O-1602 into the hippocampus via a cannula connected to an osmotic pump resulted in increased Ki67+ cells within the dentate gyrus.?O-1602 increased immature neuron generation, as assessed by DCX+ and BrdU+ cells, as compared to vehicle-treated animals.?GPR55-/- animals displayed reduced rates of proliferation and neurogenesis within the hippocampus while O-1602 had no effect as compared to vehicle controls[2].
In vivo
Intra-striatal administration of ML193 increased time on the rotarod, decreased latency to remove the label and slip steps in 6-OHDA-lesioned rats mostly at the dose of 1 g/rat[1].
AliasCID 1261822
Chemical Properties
Molecular Weight527.59
FormulaC28H25N5O4S
Cas No.713121-80-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/ml (113.72 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8954 mL9.4771 mL18.9541 mL94.7706 mL
5 mM0.3791 mL1.8954 mL3.7908 mL18.9541 mL
10 mM0.1895 mL0.9477 mL1.8954 mL9.4771 mL
20 mM0.0948 mL0.4739 mL0.9477 mL4.7385 mL
50 mM0.0379 mL0.1895 mL0.3791 mL1.8954 mL
100 mM0.0190 mL0.0948 mL0.1895 mL0.9477 mL

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