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ML-SA5
🥰Excellent
Catalog No. T60036Cas No. 2418670-70-7
ML-SA5 is a MCOLN1 agonist that blocks autophagic flux by disrupting fusion between autophagosomes and lysosomes.
ML-SA5
🥰Excellent
Purity: 100.00%
Catalog No. T60036Cas No. 2418670-70-7
ML-SA5 is a MCOLN1 agonist that blocks autophagic flux by disrupting fusion between autophagosomes and lysosomes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $33 | In Stock | |
| 5 mg | $76 | In Stock | |
| 10 mg | $133 | In Stock | |
| 25 mg | $283 | In Stock | |
| 50 mg | $455 | In Stock | |
| 100 mg | $672 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $77 | In Stock |
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Purity:100.00%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ML-SA5 is a MCOLN1 agonist that blocks autophagic flux by disrupting fusion between autophagosomes and lysosomes. |
| In vitro | METHODS: 0.05 or 0.1 μM ML-SA5 was used to treat HeLa cells 1 hour and 4 hours after the application of agonists, and the LC3-II levels in HeLa cells were observed. RESULTS ML-SA5 significantly increased the LC3-II levels. ML-SA5 regulates the LC3-II levels by stimulating the activity of MCOLN1 channels. [1] METHODS: Vero cells stably expressing GFP-Lamp1 were transfected with pStrep-mCherry-CvpE. Twenty hours after transfection, cells were treated with DMSO or ML-SA5 (30 μM) for 4 hours. Then, cells were fixed and nucleic acids were stained with DAPI. RESULTS ML-SA5 treatment completely blocked CvpE-induced cytoplasmic vacuolization. [2] |
| In vivo | METHODS: Patu 8988 t cells were injected into the subcutaneous tissue of nude mice, and ML-SA5 (5 μM) was injected into solid tumors daily. Tumor volume was measured daily, and immunohistochemistry and immunoblot analysis were performed after death of mice. RESULTS Administration of ML-SA5 profoundly promoted the survival of Patu 8988 t xenograft mice and inhibited tumor growth. [1] |
| Molecular Weight | 457.99 |
| Formula | C19H24ClN3O4S2 |
| Cas No. | 2418670-70-7 |
| Smiles | CN(C)S(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc(Cl)c1N1CCCCC1 |
| Relative Density. | 1.395 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (109.17 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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