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Molidustat

Catalog No. T2652Cas No. 1154028-82-6
Alias BAY 85-3934

Molidustat (BAY 85-3934)(BAY-85-3934), an inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH), stimulates erythropoietin (EPO) production and the formation of red blood cells.

Molidustat

Molidustat

Purity: 99.71%
Catalog No. T2652Alias BAY 85-3934Cas No. 1154028-82-6
Molidustat (BAY 85-3934)(BAY-85-3934), an inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH), stimulates erythropoietin (EPO) production and the formation of red blood cells.
Pack SizePriceAvailabilityQuantity
1 mg$45In Stock
5 mg$98In Stock
10 mg$150In Stock
25 mg$213In Stock
50 mg$328In Stock
1 mL x 10 mM (in DMSO)$108In Stock
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Purity:99.71%
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Product Introduction

Bioactivity
Description
Molidustat (BAY 85-3934)(BAY-85-3934), an inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH), stimulates erythropoietin (EPO) production and the formation of red blood cells.
Targets&IC50
PHD3:450 nM, PHD1:480 nM, PHD2:280 nM
In vitro
In vitro, Molidustat induces the transcription of hypoxia-sensitive genes in HeLa, A549, and Hep3B cells. [1]
In vivo
In healthy Wistar rats and cynomolgus monkeys, Molidustat (1.5 mg/kg, p.o.) induces dose-dependent production of EPO and erythropoiesis. In rats with gentamicin-induced renal anemiabe, Molidustat (5 mg/kg, p.o.) is also effective in raising hematocrit levels while stimulating endogenous EPO production without hypertensive effects. [1]
AliasBAY 85-3934
Chemical Properties
Molecular Weight314.3
FormulaC13H14N8O2
Cas No.1154028-82-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 11 mg/mL (35 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1817 mL15.9084 mL31.8167 mL159.0837 mL
5 mM0.6363 mL3.1817 mL6.3633 mL31.8167 mL
10 mM0.3182 mL1.5908 mL3.1817 mL15.9084 mL
20 mM0.1591 mL0.7954 mL1.5908 mL7.9542 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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