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MRK-016 is a selective GABAA α5 receptor inverse agonist/ negative allosteric modulator, (IC50=3 nM) with the advantages of being orally available and penetrating the blood-brain barrier.MRK-016 increases long time period potentiation (LTP) in mouse hippocampal slices, with memory-improvement, antidepressant, and pain-treating effects.
Description | MRK-016 is a selective GABAA α5 receptor inverse agonist/ negative allosteric modulator, (IC50=3 nM) with the advantages of being orally available and penetrating the blood-brain barrier.MRK-016 increases long time period potentiation (LTP) in mouse hippocampal slices, with memory-improvement, antidepressant, and pain-treating effects. |
Targets&IC50 | GABAA α5:3 nM (EC50), GABAA α1β3γ2 (human):0.83 nM (Ki), GABAA α3β3γ2 (human):0.77 nM (Ki), GABAA α2β3γ2 (human):0.85 nM (Ki), GABAA α5β3γ2 (human):1.4 nM (Ki) |
In vitro | MRK-016 is a selective, orally bioavailable inverse MARKET α5 receptor agonist.[1] |
In vivo | MRK-016 (0.3, 1 or 3 mg/kg, oral) exhibits cognitive enhancement activity in the delayed matching place version of the Morris water maze. [2] MRK-016 (3 mg/kg, intraperitoneal) prevents LPS-induced learning/memory impairment in mice. [3] |
Alias | MRK016 |
Molecular Weight | 368.39 |
Formula | C17H20N8O2 |
Cas No. | 342652-67-9 |
Smiles | N=1N=C(C2=NOC(=C2)C)N3N=C(OCC4=NC=NN4C)C(=C3C1)C(C)(C)C |
Relative Density. | 1.43 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (108.58 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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