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MRS1220

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Purity:96.59%

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COA HPLC HNMR

MRS1220

Catalog No. T23016Cas No. 183721-15-5

MRS1220, a selective and potent antagonist for the human A3 adenosine receptor (hA3AR) with a dissociation constant (Ki) of 0.59 nM, exhibits therapeutic promise for central nervous system disease research. It effectively diminishes glioblastoma tumor size and inhibits blood vessel formation in vivo.

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Pack Size	Price	Availability
1 mg	$45	In Stock
5 mg	$118	In Stock
10 mg	$187	In Stock
25 mg	$319	In Stock
50 mg	$460	In Stock
100 mg	$648	In Stock
500 mg	Inquiry	In Stock

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Product Introduction

Bioactivity

Description	MRS1220, a selective and potent antagonist for the human A3 adenosine receptor (hA3AR) with a dissociation constant (Ki) of 0.59 nM, exhibits therapeutic promise for central nervous system disease research. It effectively diminishes glioblastoma tumor size and inhibits blood vessel formation in vivo.
In vitro	MRS 1220 reverses the effect of A3 agonist-elicited inhibition of tumor necrosis factor-α formation in the human macrophage U-937 cell line with an IC50 of 0.3 μM[1]. VEGF secretion in U87MG glioblastoma stem-like cells (GSCs) decreases ~25% with MRS1220 after 72 h of hypoxia[2].
In vivo	MRS1220 (0.15 mg/kg; intraperitoneal inoculation) reduces tumor size and blood vessel formation in vivo. MRS1220 exhibits a strong in vivo anti-angiogenic effect[2].
Alias	MRS 1220

Chemical Properties

Molecular Weight	403.82
Formula	C21H14ClN5O2
Cas No.	183721-15-5

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility Information	DMSO: ＜1 mg/mL(insoluble or slightly soluble)

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