Shopping Cart
- Remove All
Your shopping cart is currently empty
MRS1220
🥰Excellent
Catalog No. T23016Cas No. 183721-15-5
Alias MRS 1220
MRS1220, a selective and potent antagonist for the human A3 adenosine receptor (hA3AR) with a dissociation constant (Ki) of 0.59 nM, exhibits therapeutic promise for central nervous system disease research. It effectively diminishes glioblastoma tumor size and inhibits blood vessel formation in vivo.
MRS1220
🥰Excellent
Purity: 96.59%
Catalog No. T23016Alias MRS 1220Cas No. 183721-15-5
MRS1220, a selective and potent antagonist for the human A3 adenosine receptor (hA3AR) with a dissociation constant (Ki) of 0.59 nM, exhibits therapeutic promise for central nervous system disease research. It effectively diminishes glioblastoma tumor size and inhibits blood vessel formation in vivo.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 42 € | In Stock | |
| 5 mg | 112 € | In Stock | |
| 10 mg | 177 € | In Stock | |
| 25 mg | 303 € | In Stock | |
| 50 mg | 437 € | In Stock | |
| 100 mg | 615 € | In Stock | |
| 500 mg | Inquiry | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "MRS1220"
Theobromine
3,7-Dimethylxanthine, 3, 7-Dimethylxanthine
T062583-67-0
Theobromine (3,7-Dimethylxanthine), a xanthine alkaloid, is used as a bronchodilator and as a vasodilator.
- 28 €
Size
QTY
Doxofylline
Doxophylline
T048069975-86-6
Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with significantly fewer side effects in animal and human studies.
- 31 €
Size
QTY
Theophylline monohydrate
Quibron
T1083L5967-84-0
Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Physiologically, this agent relaxes the bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates the cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm.
- 36 €
Size
QTY
Theophylline
Theo-24, 1,3-Dimethylxanthine
T108358-55-9
Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac, and central nervous system stimulant activities. It inhibits the 3', 5'-cyclic nucleotide phosphodiesterase that degrades cyclic AMP, thus potentiating the actions of agents that act through adenylyl cyclases and cyclic AMP.
- 38 €
Size
QTY
Inosine
Cited
NSC 20262, INO 495
T043758-63-9
Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties.
- 27 €
Size
QTY
CitedAdenosine 5'-monophosphate monohydrate Cited
5'-AMP monohydrate, 5'-AMP, 5'-Adenylic acid
T0853L18422-05-4
Adenosine 5'-monophosphate monohydrate (5'-AMP) , also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine. Adenosine 5'-monophosphate monohydrate consists of a phosphate group, the sugar ribose, and the nucleobase adenine. As a substituent it takes the form of the prefix adenylyl-.
- 45 €
Size
QTY
CitedAcefylline
Theophyllineacetic acid, Theophylline-7-acetic acid, Carboxymethyltheophylline, acetyloxytheophylline
T2205652-37-9
Acefylline (Theophylline-7-acetic acid), a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation Etanautine to help offset its stimulant effects
- 31 €
Size
QTY
Diphylline Cited
Dyphylline, Diprophylline
T0892479-18-5
Diphylline (Diprophylline) is a xanthine derivative. Diphylline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Diphylline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles. Diphylline may also antagonize adenosinereceptors. Diphylline is used in the treatment of acute bronchial asthma, chronic bronchitis and emphysema.
- 57 €
Size
QTY
CitedAminophylline
Phyllocontin
T1681317-34-0
Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.
- 27 €
Size
QTY
Istradefylline
KW-6002
T6552155270-99-8
Istradefylline (KW-6002)(Ki of 2.2 nM) is a selective adenosine A2A receptor (A2AR) antagonist, which is under development in Phase 3 trails. It has been used in trials studying the treatment and basic science of Drug Abuse, Sleep Disorder, Hepatic Impairment, Parkinson's Disease, and Restless Legs Syndrome, among others.
- 33 €
Size
QTY
Adenosine antagonist-1
T10248431040-19-6In house
Adenosine antagonist-1 acts as an adenosine A3 receptor (AA3R) antagonist.
- 235 €
Size
QTY
FK-453
FK453, FK 453
T27323121524-18-3In house
FK-453 is a potent antagonist of non-xanthine adenosine A1 receptor with diuretic and renal vasodilatory activity.
- 237 €
Size
QTY
Select Batch
Purity:96.59%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MRS1220, a selective and potent antagonist for the human A3 adenosine receptor (hA3AR) with a dissociation constant (Ki) of 0.59 nM, exhibits therapeutic promise for central nervous system disease research. It effectively diminishes glioblastoma tumor size and inhibits blood vessel formation in vivo. |
| In vitro | MRS 1220 reverses the A3 agonist-induced inhibition of tumor necrosis factor-α formation in the human macrophage U-937 cell line with an IC50 of 0.3 μM[1], and decreases VEGF secretion by approximately 25% in U87MG glioblastoma stem-like cells (GSCs) after 72 hours of hypoxia[2]. |
| In vivo | MRS1220 (0.15 mg/kg; intraperitoneal inoculation) significantly reduces tumor size and blood vessel formation in vivo, exhibiting a strong anti-angiogenic effect[2]. |
| Alias | MRS 1220 |
| Molecular Weight | 403.82 |
| Formula | C21H14ClN5O2 |
| Cas No. | 183721-15-5 |
| Smiles | Clc1ccc2nc(NC(=O)Cc3ccccc3)n3nc(nc3c2c1)-c1ccco1 |
| Relative Density. | 1.49 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: ＜1 mg/mL (insoluble or slightly soluble)  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy MRS1220 | purchase MRS1220 | MRS1220 cost | order MRS1220 | MRS1220 chemical structure | MRS1220 in vivo | MRS1220 in vitro | MRS1220 formula | MRS1220 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.