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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $47 | In Stock | |
5 mg | $122 | In Stock | |
10 mg | $172 | In Stock | |
25 mg | $373 | In Stock | |
50 mg | $686 | In Stock | |
100 mg | $987 | In Stock |
Description | NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration. |
In vitro | NAMI-A can significantly affect tumor cells with metastatic ability. The half-life of NAMI-A elimination from the lungs is longer than for the liver, kidney, and primary tumor. NAMI-A bound to collagen is active on tumor cells as shown in vitro by an invasion test, using a modified Boyden chamber and Matrigel, and it inhibits the matrix metallo-proteinases MMP-2 and MMP-9 at micromolar concentrations.[1] The ruthenium drug NAMI-A inhibits the adhesion and migration of colorectal cancer cells. NAMI-A decreases α5β1 integrin expression and FAK auto-phosphorylation on Tyr 397.[2] |
Molecular Weight | 458.18 |
Formula | C8H15Cl4N4ORuS |
Cas No. | 201653-76-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||
Solubility Information | H2O: 8.28 mg/mL (18.07 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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