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Naspm trihydrochloride

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Catalog No. T12187LCas No. 1049731-36-3
Alias 1-Naphthylacetyl spermine trihydrochloride

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and acts as an antagonist of calcium-permeable AMPA (CP-AMPA) receptors.

Naspm trihydrochloride

Naspm trihydrochloride

🥰Excellent
Purity: 99.75%
Catalog No. T12187LAlias 1-Naphthylacetyl spermine trihydrochlorideCas No. 1049731-36-3
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and acts as an antagonist of calcium-permeable AMPA (CP-AMPA) receptors.
Pack SizePriceAvailabilityQuantity
2 mg51 €In Stock
5 mg82 €In Stock
1 mL x 10 mM (in DMSO)87 €In Stock
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Purity:99.75%
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Product Introduction

Bioactivity
Description
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and acts as an antagonist of calcium-permeable AMPA (CP-AMPA) receptors.
Targets&IC50
AMPAR:0.33 μM
In vitro
NASPM selectively suppressed the inwardly rectifying and Ca(2+)-permeable AMPA receptors expressed in type II neurons. It had no effect on AMPA receptors in type I neurons. The blocking effect of NASPM on the Ca(2+)-permeable AMPA receptors was use and voltage-dependent. When the effect of NASPM reached a steady state, current responses induced by ionophoretic applications of kainate, a non-desensitizing agonist of AMPA receptors, in type II neurons were suppressed by NASPM in a dose-dependent manner at -60 mV (IC50 0.33 microM, and Hill coefficient 0.94). The response to kainate recovered partially after washing out NASPM. NASPM did not affect the Ca(2+)-permeable AMPA receptors when the neuronal membrane was held at potentials more positive than +40 mV. Furthermore, the blockade by NASPM which was attained at negative potentials was transiently removed by shifting membrane potential to +60 mV for 5 s together with a single ionophoretic application of kainate.
Alias1-Naphthylacetyl spermine trihydrochloride
Chemical Properties
Molecular Weight479.91
FormulaC22H37Cl3N4O
Cas No.1049731-36-3
Smiles[H]Cl.[H]Cl.[H]Cl.NCCCNCCCCNCCCNC(CC1=C2C=CC=CC2=CC=C1)=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 50 mg/mL (104.19 mM), Sonication is recommended.
DMSO: 6.4 mg/mL (13.34 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.0837 mL10.4186 mL20.8372 mL104.1862 mL
5 mM0.4167 mL2.0837 mL4.1674 mL20.8372 mL
10 mM0.2084 mL1.0419 mL2.0837 mL10.4186 mL
H2O
1mg5mg10mg50mg
20 mM0.1042 mL0.5209 mL1.0419 mL5.2093 mL
50 mM0.0417 mL0.2084 mL0.4167 mL2.0837 mL
100 mM0.0208 mL0.1042 mL0.2084 mL1.0419 mL

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