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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $54 | In Stock | |
5 mg | $87 | In Stock | |
1 mL x 10 mM (in DMSO) | $92 | In Stock |
Description | Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride) is a synthetic analogue of Joro spider toxin and is an antagonist of calcium permeable AMPA (CP-AMPA) receptors. |
In vitro | NASPM selectively suppressed the inwardly rectifying and Ca(2+)-permeable AMPA receptors expressed in type II neurons. It had no effect on AMPA receptors in type I neurons. The blocking effect of NASPM on the Ca(2+)-permeable AMPA receptors was use and voltage-dependent. When the effect of NASPM reached a steady state, current responses induced by ionophoretic applications of kainate, a non-desensitizing agonist of AMPA receptors, in type II neurons were suppressed by NASPM in a dose-dependent manner at -60 mV (IC50 0.33 microM, and Hill coefficient 0.94). The response to kainate recovered partially after washing out NASPM. NASPM did not affect the Ca(2+)-permeable AMPA receptors when the neuronal membrane was held at potentials more positive than +40 mV. Furthermore, the blockade by NASPM which was attained at negative potentials was transiently removed by shifting membrane potential to +60 mV for 5 s together with a single ionophoretic application of kainate. |
Alias | 1-Naphthylacetyl spermine trihydrochloride |
Molecular Weight | 479.91 |
Formula | C22H37Cl3N4O |
Cas No. | 1049731-36-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 50 mg/mL (104.19 mM) DMSO: 6.4 mg/mL (13.34 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
H2O
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