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NecroX-5

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Purity:99.68%

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COA HPLC LCMS HNMR

NecroX-5

Catalog No. T12204Cas No. 1383718-29-3

NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration.

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Pack Size	Price	Availability
1 mg	$46	In Stock
2 mg	$67	In Stock
5 mg	$113	In Stock
10 mg	$163	In Stock
25 mg	$262	In Stock
50 mg	$371	In Stock
100 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$161	In Stock

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Product Introduction

Bioactivity

Description	NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration.
In vitro	NecroX-5 (10-40 μM) reduces mitochondrial ROS levels and inhibits AKT and breast cancer cell migration. NecroX-5 (10 μM) blocks Ca2+ influx and decreases intracellular calcium concentration in 4T1 cells[1]. In LPS-stimulated H9C2 cells, NecroX-5 (10 µM), effectively decreases the increased TGF-β1, pSmad2, TNF-α and the expression of Dcn[2].
In vivo	In TUBO-P2J tumour-bearing mice, NecroX-5 (2.5 mg/kg) inhibits the metastasis of breast cancer cell[1].

Chemical Properties

Molecular Weight	645.81
Formula	C27H39N3O9S3
Cas No.	1383718-29-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 153.0 mg/mL (236.9 mM ), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5484 mL	7.7422 mL	15.4844 mL	77.4222 mL
5 mM	0.3097 mL	1.5484 mL	3.0969 mL	15.4844 mL
10 mM	0.1548 mL	0.7742 mL	1.5484 mL	7.7422 mL
20 mM	0.0774 mL	0.3871 mL	0.7742 mL	3.8711 mL
50 mM	0.0310 mL	0.1548 mL	0.3097 mL	1.5484 mL
100 mM	0.0155 mL	0.0774 mL	0.1548 mL	0.7742 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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