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NecroX-5
🥰Excellent
Catalog No. T12204Cas No. 1383718-29-3
NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration.
NecroX-5
🥰Excellent
Purity: 99.68%
Catalog No. T12204Cas No. 1383718-29-3
NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $46 | In Stock | |
| 2 mg | $67 | In Stock | |
| 5 mg | $113 | In Stock | |
| 10 mg | $163 | In Stock | |
| 25 mg | $262 | In Stock | |
| 50 mg | $371 | In Stock | |
| 100 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $161 | In Stock |
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Purity:99.68%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration. |
| In vitro | NecroX-5 (10-40 μM) reduces mitochondrial ROS levels and inhibits AKT and breast cancer cell migration. NecroX-5 (10 μM) blocks Ca2+ influx and decreases intracellular calcium concentration in 4T1 cells[1]. In LPS-stimulated H9C2 cells, NecroX-5 (10 µM), effectively decreases the increased TGF-β1, pSmad2, TNF-α and the expression of Dcn[2]. |
| In vivo | In TUBO-P2J tumour-bearing mice, NecroX-5 (2.5 mg/kg) inhibits the metastasis of breast cancer cell[1]. |
| Molecular Weight | 645.81 |
| Formula | C27H39N3O9S3 |
| Cas No. | 1383718-29-3 |
| Smiles | CS(O)(=O)=O.CS(O)(=O)=O.O=S1(=O)CCN(Cc2cc(NCC3CCOCC3)c3[nH]c(cc3c2)-c2ccccc2)CC1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 153.0 mg/mL (236.9 mM ), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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