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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
2 mg | $54 | In Stock | |
5 mg | $85 | In Stock | |
10 mg | $122 | In Stock | |
25 mg | $238 | In Stock | |
50 mg | $419 | In Stock | |
100 mg | $597 | In Stock | |
500 mg | $1,280 | In Stock | |
1 mL x 10 mM (in DMSO) | $88 | In Stock |
Description | NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM. |
In vitro | NIH-12848 inhibits the translocation of Na+/ K+-ATPase to the plasma membrane that occurs when mpkCCD cells grow to confluence and also prevents reversibly their forming of ‘domes' on the culture dish. NIH-12848 inhibits PI5P4Kγ with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. Both these NIH-12848-induced effects are mimicked by specific RNAi knockdown of PI5P4Kγ, but not that of PI5P4Ks α or β. NIH-12848 could be a potentially powerful tool for exploring the cell physiology of PI5P4Ks. |
Molecular Weight | 385.41 |
Formula | C20H14F3N3S |
Cas No. | 959551-10-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (142.71 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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